REL 2022-07-27 2024-02-13 2024-02-13 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) 0000-0001-6678-9436 Ximena Barros-Álvarez Stanford University Stanford California United States 94305 0000-0003-0238-7846 Georgios Skiniotis Stanford University Stanford California United States 94305 Barros-Alvarez X Kim K Panova O Roth BL Skiniotis G 3.4 10.6019/EMPIAR-11435 EMDB molecule EMD-24378 Levit A Kaplan AL Confair DN Kim K Barros-Álvarez X Rodriguiz RM Yang Y Kweon OS Che T McCorvy JD Kamber DN Phelan JP Martins LC Pogorelov VM DiBerto JF Slocum ST Huang XP Kumar JM Robertson MJ Panova O Seven AB Wetsel AQ Wetsel WC Irwin JJ Skiniotis G Shoichet BK Roth BL Ellman JA Bespoke library docking for 5-HT<sub>2A</sub> receptor agonists with antidepressant activity Nature Nature 7932 610 582 591 2022 English 10.1038/s41586-022-05258-z 36171289
The micrographs are the average of 50 raw movie frames accumulating 60.01 electron per squared Angstrom in a 2.5 sec exposure.
 Unaligned multi-frame micrographs of 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein /data micrographs - multiframe TIFF TIFF 7573 50 UNSIGNED BYTE 11520 0.42605 8184 0.42605
The micrographs are the average of 50 raw movie frames accumulating 60.01 electron per squared Angstrom in a 2.5 sec exposure.