REL
2023-06-29
2023-12-18
2023-12-18
ATTRV122I amyloid fibrils from hereditary ATTR amloidosis
0000-0002-9442-460X
Matthias
Schmidt
Institut für Proteinbiochemie, Universität Ulm
8/1 Helmholtzstrasse
Ulm
Baden Württemberg
Germany
89081
0000-0003-2123-6816
Marcus
Fändrich
Institut für Proteinbiochemie, Universität Ulm
8/1 Helmholtzstrasse
Ulm
Baden Württemberg
Germany
89081
Steinebrei M
Schmidt M
Fändrich M
German Research Foundation (DFG)
FA 456/28
Germany
644.5
10.6019/EMPIAR-11704
EMDB
molecule
EMD-17738
Steinebrei M
Baur J
Pradhan A
Kupfer N
Wiese S
Hegenbart U
Schönland SO
Schmidt M
Fändrich M
Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis
Nature communications
Nat Commun
1
14
2023
English
10.1038/s41467-023-43301-3
37993462
Unaligned multi-frame micrographs of ATTRV122I amyloid fibrils
/data/Micrographs_raw_V122I
micrographs - multiframe
TIFF
TIFF
2068
40
UNSIGNED 16 BIT INTEGER
variable
1.04
variable
1.04
Krios1 Quantum-K2
Cs 2.7
300kV EFTEM nanpprobe
x130k spot 8 beam size 650nm
c2=50 objective_aperture=100
GIF-K2 counting
10s exposure 40 frames
total dose at the sample 57.70e/A2 --> dose per frame 1.4425
1 pixel = 1.04A
dose rate ~3-4 e/pix/s
defocus range -1.2 to -2.5