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            <depositionDate>2024-01-27</depositionDate>
            <releaseDate>2024-03-26</releaseDate>
            <updateDate>2024-03-26</updateDate>
        </keyDates>
        <title>Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-6565-8095</authorORCID>
            <firstName>Feng</firstName>
            <lastName>Wang</lastName>
            <organization type="academic">Department of Structural Biology, Van Andel Reseearch Institute</organization>
            <street>333 Bostwick Ave. NE</street>
            <townOrCity>Grand Rapids</townOrCity>
            <stateOrProvince>Michigen</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>49503</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0001-8085-8928</authorORCID>
            <firstName>Huilin</firstName>
            <lastName>Li</lastName>
            <organization type="academic">Department of Structural Biology  Van Andel institute</organization>
            <street>333 Bostwick Ave. NE</street>
            <townOrCity>Grand Rapids</townOrCity>
            <stateOrProvince>MI</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>49503</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0002-6565-8095">Wang FW</author>
        </authorsList>
        <grantSupport>
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                <code></code>
                <country></country>
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        <datasetSize units="TB">7.6</datasetSize>
        <entryDOI>10.6019/EMPIAR-11878</entryDOI>
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        <scale>molecule</scale>
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    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-28646</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0002-6565-8095" order="1">Wang F</author>
                    <author authorORCID="0000-0002-8414-2430" order="2">He Q</author>
                    <author authorORCID="0000-0002-7095-7081" order="3">Zhan W</author>
                    <author order="4">Yu Z</author>
                    <author order="5">Finkin-Groner E</author>
                    <author order="6">Ma X</author>
                    <author order="7">Lin G</author>
                    <author authorORCID="0000-0001-8085-8928" order="8">Li H</author>
                    <title>Structure of the human UBR5 E3 ubiquitin ligase</title>
                    <journal>Structure (London, England : 1993)</journal>
                    <journalAbbreviation>Structure</journalAbbreviation>
                    <country>United States</country>
                    <issue>5</issue>
                    <volume>31</volume>
                    <firstPage>541</firstPage>
                    <lastPage>552.e4</lastPage>
                    <year>2023</year>
                    <language>English</language>
                    <externalReferences type="doi">10.1016/j.str.2023.03.010</externalReferences>
                    <externalReferences type="pubmed">37040767</externalReferences>
                    <details>raw movies with no realignment, with 75 frames per stack.</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>unaligned multi-frame micrographs of the tetrameric form of the giant E3 liagse UBR5</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>17529</numImagesOrTiltSeries>
        <framesPerImage>75</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.414</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.414</pixelHeight>
        </dimensions>
        <details>The micrographs are the average, without any realigment, of 75 raw movie frames (accumulating 65 electron per squared Angstrom in a 1.5 second exposure). All micrographs tilted at 20 degree</details>
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        <micrographsFilePattern>data/movies</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
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