REL 2024-02-01 2024-06-27 2024-06-27 E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800 0000-0001-9325-3207 Dmitry Ghilarov John Innes Centre Colney Lane Norwich Norfolk United Kingdom NR4 7UH 0000-0001-9325-3207 Dmitry Ghilarov John Innes Centre Norwich United Kingdom NR4 7UH Bakker A.T. Kotsogianni I Avalos M. Punt J.M. Liu B. Piermarini D. Gagestein B. Slingerland C.J. Zhang L. Willemse J.J. Ghimire L.B. van den Berg R.J.H.B.N. Janssen A.P.A. Ottenhoff T.H.M. van Boeckel C.A.A. van Wezel G.P. Ghilarov D. Martin N.I. van der Stelt M. 5.2 10.6019/EMPIAR-11884 EMDB molecule EMD-18592 Bakker A.T. Kotsogianni I Avalos M. Punt J.M. Liu B. Piermarini D. Gagestein B. Slingerland C.J. Zhang L. Willemse J.J. Ghimire L.B. van den Berg R.J.H.B.N. Janssen A.P.A. Ottenhoff T.H.M. van Boeckel C.A.A. van Wezel G.P. Ghilarov D. Martin N.I. van der Stelt M. Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria Nature Chemistry Nat. Chem. United Kingdom 2024 English Unaligned multi-frame micrographs in the EER format of LEI-800-217bp DNA - Escherichia coli gyrase complex /data micrographs - multiframe EER EER 17017 639 BIT 4096 0.68 4096 0.68
A dose per physical pixel of 8.8 e-/s was used, resulting in a total electron dose of 39.58 e-/Å2, fractionated across 639 EPU frames. Grouping into 49 frames will result in an electron dose of 0.8 e-/Å2 per frame.