REL
2025-01-03
2026-03-02
2026-03-02
Patient derived AD PHF with PET Ligand MK-6240
0000-0001-9752-7287
Sarah
H.
Shahmoradian
UTSW Medical Center
6000 Harry Hines Blvd
Dallas
Texas
United States
75235
0000-0001-9752-7287
Sarah
H.
Shahmoradian
UTSW Medical Center
6000 Harry Hines Blvd
Dallas
Texas
United States
75235
Kunach P
Vaquer-Alicea J
Smith MS
Monistrol J
Hopewell R
Moquin L
Therriault J
Tissot C
Rahmouni N
Massarweh G
Soucy JP
Guiot MC
Shoichet BK
Rosa-Neto P
Diamond MI
Shahmoradian SH
Cancer Prevention and Research Institute of Texas (CPRIT)
RP170644
United States
Canadian Institutes of Health Research (CIHR)
MOP-11-51-31
Canada
Fonds de la Recherche Scientifique (FNRS)
152985
Canada
Fonds de Recherche du Quebec - Sante (FRQS)
2020-VICO-279314
Canada
National Institutes of Health (NIH)
R35GM122481
United States
7.4
10.6019/EMPIAR-12870
EMDB
molecule
EMD-42463
Kunach P
Vaquer-Alicea J
Smith MS
Monistrol J
Hopewell R
Moquin L
Therriault J
Tissot C
Rahmouni N
Massarweh G
Soucy JP
Guiot MC
Shoichet BK
Rosa-Neto P
Diamond MI
Shahmoradian SH
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240
Nature communications
Nat Commun
1
15
8497
8497
2024
English
10.1038/s41467-024-52265-x
39353896
RAW movies collected using CDS mode, total dose of 62 e/A2, 8EPS. 0.415A super resolution pixel size.
Unaligned multi-frame movies of tau filaments from sporadic AD complexed to PET ligand MK-6240 (10uM)
/data/RAW_Tif
micrographs - multiframe
TIFF
TIFF
3978
50
UNSIGNED BYTE
11520
0.415
8184
0.415
dose per frame: ~1.04 e-/A2/frame;
data/RAW_Tif/Peter_08032022_119-1_00001_X-1Y-1-1.tif
data/job004/manualpick.star
data/job004/RAW_Tif
Unaligned multi-frame movies of tau filaments from sporadic AD incubated with pan-Amyloid dye Thioflavin T (10uM)
/data/RAW_Tif_ThT
micrographs - multiframe
TIFF
TIFF
4195
50
UNSIGNED BYTE
11520
0.415
8184
0.415
dose per frame: ~1.04 e-/A2/frame;
data/RAW_Tif_ThT/Peter_08042022_124-1_00009_X+1Y-1-3.tif
data/ManualPick_ThT
data/ManualPick_ThT/RAW_Tif
Unaligned multi-frame movies of tau filaments from sporadic AD incubated with 3% DMSO
/data/RAW_TIF_DMSO_Control
micrographs - multiframe
TIFF
TIFF
3842
60
UNSIGNED BYTE
11520
0.415
8184
0.415
dose per frame: ~1.0 e-/A2/frame;
data/RAW_TIF_DMSO_Control/AD_ctrl_2_00018_13.40.38.tif
data/ManualPick_DMSO_Control/RAW_TIF_Combined_Keep/AD_ctrl_2_00018_13_40_38_manualpick.star
data/ManualPick_DMSO_Control
Unaligned multi-frame movies of tau filaments from sporadic AD incubated native condition
/data/RAW_TIF_Native
micrographs - multiframe
TIFF
TIFF
5360
50
UNSIGNED BYTE
11520
0.415
8184
0.415
dose per frame: ~1.04 e-/A2/frame;
data/RAW_TIF_Native
data/ManualPick_Native
data/ManualPick_Native/RAW_TIF