<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-13505" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2026-04-20</depositionDate>
            <releaseDate>2026-04-23</releaseDate>
            <updateDate>2026-04-23</updateDate>
        </keyDates>
        <title>SMC5 modulates BAT thermogenesis and energy expenditure via cell cycle arrest-induced RB accumulation</title>
        <correspondingAuthor private="true">
            <firstName>Jie</firstName>
            <lastName>Qiao</lastName>
            <organization type="academic">Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine</organization>
            <townOrCity>Shanghai</townOrCity>
            <stateOrProvince>Shanghai</stateOrProvince>
            <country>China</country>
            <postOrZipCode>200011</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <firstName>Jie</firstName>
            <lastName>Qiao</lastName>
            <organization type="academic">Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine</organization>
            <townOrCity>Shanghai</townOrCity>
            <stateOrProvince>Shanghai</stateOrProvince>
            <country>China</country>
            <postOrZipCode>200011</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author>Ling S</author>
            <author>Jiang Y</author>
            <author>Lu D</author>
            <author>Cao R</author>
            <author>Xu Y</author>
            <author>Zhu W</author>
            <author>Zhu H</author>
            <author>Han B</author>
            <author>Zhou Y</author>
            <author>Yang Y</author>
            <author>Ge Z</author>
            <author>Liang Y</author>
            <author>Shen H</author>
            <author>Zhao S</author>
            <author>Hua Y</author>
            <author>Shen WL</author>
            <author>Song H</author>
            <author>Qiao J</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody></fundingBody>
                <code></code>
                <country></country>
            </grantReference>
        </grantSupport>
        <datasetSize units="GB">233.3</datasetSize>
        <entryDOI>10.6019/EMPIAR-13505</entryDOI>
        <experimentType>SBF-SEM</experimentType>
        <scale>cell</scale>
    </admin>
    <crossReferences>
        <citationList>
            <universalCitation>
                <journalCitation published="false" preprint="false">
                    <author order="1">Ling S</author>
                    <author order="2">Jiang Y</author>
                    <author order="3">Lu D</author>
                    <author order="4">Cao R</author>
                    <author order="5">Xu Y</author>
                    <author order="6">Zhu W</author>
                    <author order="7">Zhu H</author>
                    <author order="8">Han B</author>
                    <author order="9">Zhou Y</author>
                    <author order="10">Yang Y</author>
                    <author order="11">Ge Z</author>
                    <author order="12">Liang Y</author>
                    <author order="13">Shen H</author>
                    <author order="14">Zhao S</author>
                    <author order="15">Hua Y</author>
                    <author order="16">Shen WL</author>
                    <author order="17">Song H</author>
                    <author order="18">Qiao J</author>
                    <title>SMC5 modulates BAT thermogenesis and energy expenditure via cell cycle arrest-induced RB accumulation</title>
                    <journal>Nature Metabolism</journal>
                    <journalAbbreviation>Nat. Metabolism</journalAbbreviation>
                    <country>United Kingdom</country>
                    <language>English</language>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>WT</name>
        <directory>/data/WT</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>1039</numImagesOrTiltSeries>
        <framesPerImage>1</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>10374</imageWidth>
            <pixelWidth>variable</pixelWidth>
            <imageHeight>10094</imageHeight>
            <pixelHeight>variable</pixelHeight>
        </dimensions>
        <details>The tiff image sequences of wildtype contain 1039 SBF-SEM continued aligned images. The pixel size of the dataset is 10nm*10nm*60nm.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
    <imageSet>
        <name>Smc5K371/K371</name>
        <directory>/data/Smc5K371:K371</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>1463</numImagesOrTiltSeries>
        <framesPerImage>1</framesPerImage>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>9424</imageWidth>
            <pixelWidth>variable</pixelWidth>
            <imageHeight>11223</imageHeight>
            <pixelHeight>variable</pixelHeight>
        </dimensions>
        <details>The tiff image sequences of Smc5K371/371 contain 1463 SBF-SEM continued aligned images. The pixel size of the dataset is 10nm*10nm*60nm.</details>
        <segmentationList/>
        <micrographsFilePattern></micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
