<entry xmlns="http://pdbe.org/empiar" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="https://ftp.ebi.ac.uk/pub/databases/emtest/empiar/schema/empiar.xsd" accessionCode="EMPIAR-13517" schemaVersion="0.65" public="true">
    <admin>
        <currentStatus>REL</currentStatus>
        <keyDates>
            <depositionDate>2025-09-15</depositionDate>
            <releaseDate>2026-05-05</releaseDate>
            <updateDate>2026-05-05</updateDate>
        </keyDates>
        <title>Raw multi-frame images of SUR1/Kir6.2 ATP-sensitive potassium channel in the presence of Aekatperone and ATP</title>
        <correspondingAuthor private="true">
            <authorORCID>0000-0002-2105-7175</authorORCID>
            <firstName>Camden</firstName>
            <middleName>M</middleName>
            <lastName>Driggers</lastName>
            <organization type="academic">Department of Chemical Physiology and Biochemistry, Oregon Health &amp; Science University, United States</organization>
            <street>3181 SW Sam Jackson Park Rd; Medical Research Building rm. 624</street>
            <townOrCity>Portland</townOrCity>
            <stateOrProvince>Oregon</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>97239</postOrZipCode>
        </correspondingAuthor>
        <principalInvestigator private="true">
            <authorORCID>0000-0002-8230-8820</authorORCID>
            <firstName>Show-Ling</firstName>
            <lastName>Shyng</lastName>
            <organization type="academic">Department of Chemical Physiology and Biochemistry, Oregon Health &amp; Science University, United States</organization>
            <street>3181 SW Sam Jackson Park Rd; Medical Research Building rm. 624A</street>
            <townOrCity>Portland</townOrCity>
            <stateOrProvince>Oregon</stateOrProvince>
            <country>United States</country>
            <postOrZipCode>97239</postOrZipCode>
        </principalInvestigator>
        <authorsList>
            <author authorORCID="0000-0002-2105-7175">Driggers CM</author>
            <author authorORCID="0000-0001-7360-9309">Elsheikh A</author>
            <author authorORCID="0000-0002-8230-8820">Shyng SL</author>
        </authorsList>
        <grantSupport>
            <grantReference>
                <fundingBody>National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)</fundingBody>
                <code>DK066485</code>
                <country>United States</country>
            </grantReference>
            <grantReference>
                <fundingBody>National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)</fundingBody>
                <code>GM129547</code>
                <country>United States</country>
            </grantReference>
        </grantSupport>
        <datasetSize units="TB">16.3</datasetSize>
        <entryDOI>10.6019/EMPIAR-13517</entryDOI>
        <experimentType>EMDB</experimentType>
        <scale>molecule</scale>
    </admin>
    <crossReferences>
        <relatedEMDBEntries>
            <emdbEntry>EMD-46820</emdbEntry>
        </relatedEMDBEntries>
        <citationList>
            <universalCitation>
                <journalCitation published="true" preprint="false">
                    <author authorORCID="0000-0001-7360-9309" order="1">Elsheikh A</author>
                    <author authorORCID="0000-0002-2105-7175" order="2">Driggers CM</author>
                    <author order="3">Truong HH</author>
                    <author authorORCID="0000-0003-4686-0869" order="4">Yang Z</author>
                    <author order="5">Allen J</author>
                    <author order="6">Henriksen NM</author>
                    <author authorORCID="0000-0001-6422-6138" order="7">Walczewska-Szewc K</author>
                    <author authorORCID="0000-0002-8230-8820" order="8">Shyng SL</author>
                    <title>AI-based discovery and cryoEM structural elucidation of a K&amp;lt;sub&amp;gt;ATP&amp;lt;/sub&amp;gt; channel pharmacochaperone</title>
                    <journal>eLife</journal>
                    <journalAbbreviation>Elife</journalAbbreviation>
                    <country></country>
                    <issue>RP103159</issue>
                    <volume>13</volume>
                    <firstPage>RP103159</firstPage>
                    <lastPage>RP103159</lastPage>
                    <year>2025</year>
                    <language>English</language>
                    <externalReferences type="doi">10.7554/elife.103159</externalReferences>
                    <externalReferences type="pubmed">40135739</externalReferences>
                    <details>These are all raw multi-frame images, without curation, alignment or correction, which were collected in April and June of 2023 on PNCC Krios #3 (K3) from Ultrathin C Film Lacey Carbon, 400 mesh, Cu grids with  SUR1/Kir6.2 ATP-sensitive potassium channels in the presence of Aekatperone and ATP</details>
                </journalCitation>
            </universalCitation>
        </citationList>
    </crossReferences>
    <imageSet>
        <name>Unaligned multi-frame micrographs of Kir6.2+SUR1 KATP channels bound to Aekatperone and ATP</name>
        <directory>/data</directory>
        <category>micrographs - multiframe</category>
        <headerFormat>TIFF</headerFormat>
        <dataFormat>TIFF</dataFormat>
        <numImagesOrTiltSeries>31513</numImagesOrTiltSeries>
        <framesPerImage>74</framesPerImage>
        <frameRange>
            <frameRangeMin>1</frameRangeMin>
            <frameRangeMax>74</frameRangeMax>
        </frameRange>
        <voxelType>UNSIGNED BYTE</voxelType>
        <dimensions>
            <imageWidth>11520</imageWidth>
            <pixelWidth>0.52575</pixelWidth>
            <imageHeight>8184</imageHeight>
            <pixelHeight>0.52575</pixelHeight>
        </dimensions>
        <details></details>
        <segmentationList/>
        <micrographsFilePattern>data/tif*/*.tif</micrographsFilePattern>
        <pickedParticlesFilePattern></pickedParticlesFilePattern>
        <pickedParticlesDirectory></pickedParticlesDirectory>
    </imageSet>
</entry>
