REL
2026-05-19
2026-06-23
2026-06-23
Cryo-EM structure of rat SLCO2A1 bound to losartan.
0000-0003-0045-964X
Chitra
Joshi
Department of Biochemistry, University of Oxford
South Parks Road
Oxford
Oxfordshire
United Kingdom
OX1 3QU
0000-0001-7432-2270
Simon
Newstead
Department of Biochemistry, University of Oxford
South Parks Road
Oxford
Oxfordshire
United Kingdom
OX1 3QU
Joshi C
Newstead S
Wellcome Trust
215519/Z/19/Z
United Kingdom
Wellcome Trust
219531/Z/19/Z
United Kingdom
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/Z517215/1
United Kingdom
Engineering and Physical Sciences Research Council
EP/X035603/1
United Kingdom
Japan Society for the Promotion of Science (JSPS)
24K09819
Japan
Japan Society for the Promotion of Science (JSPS)
22K15295
Japan
5.0
10.6019/EMPIAR-13591
EMDB
molecule
EMD-53483
Joshi C
Deme JC
Nakamura Y
Hsu WT
Goult JD
Kato T
Parker JL
Biggin PC
Lea SM
Nakanishi T
Newstead S
Structural basis for prostaglandin and drug transport via SLCO2A1
Nature communications
Nat Commun
United Kingdom
1
17
2026
English
10.1038/s41467-026-70227-3
41862483
The micrographs are the raw movie frames (4092x5760) collected on a 300kV Titan Krios microscope. The datasets are organised into 3 sets with following parameters:
Set I: 8575 movies, Total dose 40.2 e/Å^2, Pixel size 0.832Å, TIFF format. No tilt series.
Set II: 4106 movies, Total dose 49.2 e/Å^2, Pixel size 0.832Å, TIFF format. No tilt series.
Set III: 13,660 movies, Total dose 46.22 e/Å^2 , Pixel size 0.832Å, TIFF format. No tilt series.
Raw and unaligned multi frame movies for rat SLCO2A1 bound to losartan.
/data
micrographs - multiframe
TIFF
TIFF
26341
40
UNSIGNED BYTE
variable
variable
variable
variable
The micrographs are the raw movie frames (4092x5760) collected on a 300kV Titan Krios microscope. The datasets are organised into 3 sets with following parameters:
Set I: 8575 movies, Total dose 40.2 e/Å^2, Pixel size 0.832Å, TIFF format. No tilt series.
Set II: 4106 movies, Total dose 49.2 e/Å^2, Pixel size 0.832Å, TIFF format. No tilt series.
Set III: 13,660 movies, Total dose 46.22 e/Å^2 , Pixel size 0.832Å, TIFF format. No tilt series.
data