{"schema_version":"1.0","pdb_id":"4UIS","generated_at":"2026-09-04T05:15:40Z","status":"complete","coordinate_system":{"reference":"PDB_INSTANCE","index_base":1,"end_inclusive":true},"sources":{"sequence_coordinates_api":"https://sequence-coordinates.rcsb.org/graphql","annotation_collections":["UNIPROT","PDB_ENTITY","PDB_INSTANCE","PDB_INTERFACE"]},"chains":[{"instance_id":"4UIS.E","entity_id":"5","label_asym_id":"E","auth_asym_id":"G","description":"LYSOZYME","polymer_type":"polypeptide(L)","sequence":{"value":"MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYK","length":162},"alignments":[{"source":"UNIPROT","target_id":"D9IEF7","target_sequence":"MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL","query_coverage":1.0,"query_length":162,"target_coverage":0.9878048780487805,"target_length":164,"orientation":null,"regions":[{"query_begin":1,"query_end":162,"target_begin":1,"target_end":162,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":6,"end":12,"feature_id":"HELX_P43","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":6,"original_end":12},{"begin":17,"end":19,"feature_id":"GA","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":17,"original_end":19},{"begin":25,"end":27,"feature_id":"GA","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":25,"original_end":27},{"begin":31,"end":34,"feature_id":"GA","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":31,"original_end":34},{"begin":38,"end":51,"feature_id":"HELX_P44","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":38,"original_end":51},{"begin":59,"end":75,"feature_id":"HELX_P45","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":59,"original_end":75},{"begin":77,"end":81,"feature_id":"HELX_P46","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":77,"original_end":81},{"begin":83,"end":91,"feature_id":"HELX_P47","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":83,"original_end":91},{"begin":92,"end":106,"feature_id":"HELX_P48","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":92,"original_end":106},{"begin":107,"end":113,"feature_id":"HELX_P49","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":107,"original_end":113},{"begin":114,"end":123,"feature_id":"HELX_P50","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":114,"original_end":123},{"begin":125,"end":134,"feature_id":"HELX_P51","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":125,"original_end":134},{"begin":142,"end":156,"feature_id":"HELX_P52","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":142,"original_end":156},{"begin":158,"end":162,"feature_id":"HELX_P53","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"PROMOTIF","original_begin":158,"original_end":162}]},{"key":"buried_residues","label":"BURIED RESIDUES","kind":"point","features":[{"begin":1,"end":162,"feature_id":null,"type":"BURIED_RESIDUES","name":"Unbound chain core residues","description":"Residue accessibility lower than 6Å","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"NBDB derivation matching RCSB Saguaro App","original_begin":1,"original_end":null,"values":[0,0,0,0,0,2.87,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.1,0,0,5.84,0,0,3.35,2.68,0,0,0,0,0,0,0,0,4.03,0,0,0,1.18,0,0,0,0,0,0,0,0,0,0.5,0.53,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.43,3.76,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.7,0,0,0,0,0,0,0,0,0,0,0.26,0,0,0,0,0,0,0,0,0,0,0,0,0]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":158,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_5","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.88,0.28,0.28,-0.27,-0.16,-0.27,-0.06,-0.91,0.09,-0.56,-0.6,-0.6,-0.63,-1.44,-0.99,-1.56,-1.27,-1.84,-1.2,-0.81,0.08,0.11,0.14,0.61,1.18,1.24,0.89,0.3,0.17,-0.42,0.04,0.01,-0.21,-0.43,-0.79,-0.44,-0.74,-0.14,-0.44,-1.3,-0.71,-0.41,-0.66,-0.72,-1.02,-0.36,-1.17,-0.82,0.08,0.38,-0.2,-0.59,-0.48,-0.48,-0.56,-0.56,-0.94,-0.99,-1.18,-1.49,-1.44,-1.44,-0.59,-1.18,-0.59,0.04,0.09,-0.72,-0.38,0.51,1.32,0.36,0.36,0.36,-0.28,-0.32,-0.26,-0.39,-0.42,-0.99,-0.88,-0.58,-0.36,-0.31,-0.53,0.37,0.04,-0.92,-0.5,0.09,0.6,0.68,0.68,0.69,0.69,1.5,1.61,1.54,1.3,0.49,-0.09,0.26,0.51,0.24,-0.11,0.59,0.3,-0.04,0.26,0.76,0.3,0.04,0.27,-0.08,-0.78,-1.13,-1.24,-1.26,-2.07,-1.96,-1.97,-2.19,-1.33,-1.33,-0.48,0.22,-0.11,0.19,0.08,-0.22,-0.57,-1.42,-1.42,-1.92,-2.3,-2.26,-2.67,-1.97,-2.3,-2.66,-1.8,-0.91,-0.91,-0.81,-0.11,-0.11,-0.39,0.0,0.42,-0.14,-1.03,-0.76,-0.82,-1.57]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":162,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_5","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.62,0.57,0.44,0.4,0.27,0.22,0.12,0.05,0.04,0.03,0.02,0.04,0.04,0.04,0.04,0.04,0.03,0.05,0.03,0.06,0.06,0.04,0.02,0.04,0.04,0.07,0.09,0.16,0.17,0.17,0.14,0.12,0.1,0.11,0.17,0.18,0.19,0.27,0.25,0.25,0.26,0.26,0.33,0.35,0.35,0.36,0.3,0.2,0.19,0.26,0.27,0.3,0.3,0.31,0.31,0.23,0.22,0.22,0.23,0.27,0.28,0.28,0.24,0.21,0.21,0.2,0.2,0.17,0.16,0.17,0.17,0.13,0.13,0.1,0.09,0.12,0.12,0.11,0.12,0.11,0.06,0.1,0.08,0.06,0.08,0.12,0.08,0.06,0.06,0.06,0.07,0.05,0.05,0.03,0.05,0.04,0.03,0.05,0.08,0.07,0.05,0.07,0.06,0.05,0.07,0.07,0.07,0.06,0.08,0.11,0.12,0.12,0.15,0.21,0.31,0.23,0.27,0.27,0.24,0.22,0.17,0.24,0.21,0.19,0.29,0.29,0.29,0.22,0.22,0.23,0.27,0.34,0.36,0.35,0.35,0.32,0.39,0.39,0.35,0.31,0.33,0.38,0.3,0.37,0.38,0.38,0.38,0.29,0.35,0.41,0.33,0.32,0.37,0.38,0.41,0.46,0.52,0.56,0.61,0.69,0.78,0.82]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":162,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_5","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.24,0.24,0.24,0.24,0.24,0.24,0.23,0.23,0.22,0.22,0.22,0.22,0.23,0.23,0.24,0.24,0.25,0.25,0.26,0.26,0.27,0.28,0.29,0.3,0.31,0.31,0.31,0.31,0.32,0.33,0.34,0.34,0.33,0.32,0.31,0.3,0.3,0.3,0.29,0.28,0.28,0.27,0.26,0.26,0.27,0.27,0.27,0.27,0.27,0.27,0.28,0.28,0.28,0.28,0.28,0.28,0.29,0.29,0.29,0.29,0.29,0.29,0.29,0.3,0.31,0.32,0.32,0.31,0.31,0.32,0.32,0.32,0.32,0.32,0.32,0.32,0.31,0.32,0.33,0.33,0.33,0.33,0.34,0.35,0.35,0.35,0.35,0.35,0.35,0.36,0.36,0.37,0.37,0.39,0.4,0.41,0.43,0.43,0.43,0.43,0.42,0.42,0.41,0.4,0.38,0.36,0.34,0.32,0.32,0.31,0.32,0.32,0.32,0.33,0.33,0.34,0.36,0.37,0.38,0.38,0.39,0.38,0.38,0.39,0.39,0.4,0.39,0.39,0.4,0.41,0.41,0.41,0.42,0.42,0.41,0.41,0.41,0.41,0.4,0.4,0.39,0.39,0.4,0.4,0.41,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.42,0.42,0.41,0.41,0.41,0.41,0.4,0.4,0.4]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":1,"end":162,"feature_id":"e4uisG1","type":"ECOD","name":"SRP_SPB","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.E","provenance_source":"ECOD","original_begin":1,"original_end":162}]},{"key":"active_site","label":"ACTIVE SITE","kind":"point","features":[{"begin":11,"end":11,"feature_id":null,"type":"ACTIVE_SITE","name":null,"description":"Proton donor/acceptor","value":null,"source":"UNIPROT","source_id":"D9IEF7","provenance_source":null,"original_begin":11,"original_end":11},{"begin":20,"end":20,"feature_id":null,"type":"ACTIVE_SITE","name":null,"description":"Proton donor/acceptor","value":null,"source":"UNIPROT","source_id":"D9IEF7","provenance_source":null,"original_begin":20,"original_end":20}]}]},{"instance_id":"4UIS.D","entity_id":"4","label_asym_id":"D","auth_asym_id":"D","description":"GAMMA-SECRETASE","polymer_type":"polypeptide(L)","sequence":{"value":"XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX","length":62},"alignments":[],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":3,"end":13,"feature_id":"HELX_P38","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PROMOTIF","original_begin":3,"original_end":13},{"begin":14,"end":16,"feature_id":"HELX_P39","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PROMOTIF","original_begin":14,"original_end":16},{"begin":17,"end":27,"feature_id":"HELX_P40","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PROMOTIF","original_begin":17,"original_end":27},{"begin":30,"end":59,"feature_id":"HELX_P41","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PROMOTIF","original_begin":30,"original_end":59},{"begin":60,"end":62,"feature_id":"HELX_P42","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PROMOTIF","original_begin":60,"original_end":62}]},{"key":"buried_residues","label":"BURIED RESIDUES","kind":"point","features":[{"begin":1,"end":62,"feature_id":null,"type":"BURIED_RESIDUES","name":"Unbound chain core residues","description":"Residue accessibility lower than 6Å","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"NBDB derivation matching RCSB Saguaro App","original_begin":1,"original_end":null,"values":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":58,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":62,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.92,0.89,0.85,0.8,0.75,0.71,0.66,0.61,0.56,0.51,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.51,0.56,0.61,0.66,0.71,0.75,0.8,0.85,0.89,0.92]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":62,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15]}]},{"key":"other_membrane_segment","label":"MEMBRANE_SEGMENT","kind":"range","features":[{"begin":6,"end":14,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"OPM","original_begin":6,"original_end":14},{"begin":12,"end":22,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PDBTM","original_begin":12,"original_end":22},{"begin":17,"end":25,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"OPM","original_begin":17,"original_end":25},{"begin":35,"end":43,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"OPM","original_begin":35,"original_end":43},{"begin":40,"end":52,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.D","provenance_source":"PDBTM","original_begin":40,"original_end":52}]},{"key":"other_modified_monomer","label":"MODIFIED_MONOMER","kind":"point","features":[{"begin":1,"end":1,"feature_id":"monomer_feature_397","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":1,"original_end":1},{"begin":2,"end":2,"feature_id":"monomer_feature_398","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":2,"original_end":2},{"begin":3,"end":3,"feature_id":"monomer_feature_399","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":3,"original_end":3},{"begin":4,"end":4,"feature_id":"monomer_feature_400","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":4,"original_end":4},{"begin":5,"end":5,"feature_id":"monomer_feature_401","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":5,"original_end":5},{"begin":6,"end":6,"feature_id":"monomer_feature_402","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":6,"original_end":6},{"begin":7,"end":7,"feature_id":"monomer_feature_403","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":7,"original_end":7},{"begin":8,"end":8,"feature_id":"monomer_feature_404","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":8,"original_end":8},{"begin":9,"end":9,"feature_id":"monomer_feature_405","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":9,"original_end":9},{"begin":10,"end":10,"feature_id":"monomer_feature_406","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":10,"original_end":10},{"begin":11,"end":11,"feature_id":"monomer_feature_407","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":11,"original_end":11},{"begin":12,"end":12,"feature_id":"monomer_feature_408","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":12,"original_end":12},{"begin":13,"end":13,"feature_id":"monomer_feature_409","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":13,"original_end":13},{"begin":14,"end":14,"feature_id":"monomer_feature_410","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":14,"original_end":14},{"begin":15,"end":15,"feature_id":"monomer_feature_411","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":15,"original_end":15},{"begin":16,"end":16,"feature_id":"monomer_feature_412","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":16,"original_end":16},{"begin":17,"end":17,"feature_id":"monomer_feature_413","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":17,"original_end":17},{"begin":18,"end":18,"feature_id":"monomer_feature_414","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":18,"original_end":18},{"begin":19,"end":19,"feature_id":"monomer_feature_415","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":19,"original_end":19},{"begin":20,"end":20,"feature_id":"monomer_feature_416","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":20,"original_end":20},{"begin":21,"end":21,"feature_id":"monomer_feature_417","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":21,"original_end":21},{"begin":22,"end":22,"feature_id":"monomer_feature_418","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":22,"original_end":22},{"begin":23,"end":23,"feature_id":"monomer_feature_419","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":23,"original_end":23},{"begin":24,"end":24,"feature_id":"monomer_feature_420","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":24,"original_end":24},{"begin":25,"end":25,"feature_id":"monomer_feature_421","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":25,"original_end":25},{"begin":26,"end":26,"feature_id":"monomer_feature_422","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":26,"original_end":26},{"begin":27,"end":27,"feature_id":"monomer_feature_423","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":27,"original_end":27},{"begin":28,"end":28,"feature_id":"monomer_feature_424","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":28,"original_end":28},{"begin":29,"end":29,"feature_id":"monomer_feature_425","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":29,"original_end":29},{"begin":30,"end":30,"feature_id":"monomer_feature_426","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":30,"original_end":30},{"begin":31,"end":31,"feature_id":"monomer_feature_427","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":31,"original_end":31},{"begin":32,"end":32,"feature_id":"monomer_feature_428","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":32,"original_end":32},{"begin":33,"end":33,"feature_id":"monomer_feature_429","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":33,"original_end":33},{"begin":34,"end":34,"feature_id":"monomer_feature_430","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":34,"original_end":34},{"begin":35,"end":35,"feature_id":"monomer_feature_431","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":35,"original_end":35},{"begin":36,"end":36,"feature_id":"monomer_feature_432","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":36,"original_end":36},{"begin":37,"end":37,"feature_id":"monomer_feature_433","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":37,"original_end":37},{"begin":38,"end":38,"feature_id":"monomer_feature_434","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":38,"original_end":38},{"begin":39,"end":39,"feature_id":"monomer_feature_435","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":39,"original_end":39},{"begin":40,"end":40,"feature_id":"monomer_feature_436","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":40,"original_end":40},{"begin":41,"end":41,"feature_id":"monomer_feature_437","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":41,"original_end":41},{"begin":42,"end":42,"feature_id":"monomer_feature_438","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":42,"original_end":42},{"begin":43,"end":43,"feature_id":"monomer_feature_439","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":43,"original_end":43},{"begin":44,"end":44,"feature_id":"monomer_feature_440","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":44,"original_end":44},{"begin":45,"end":45,"feature_id":"monomer_feature_441","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":45,"original_end":45},{"begin":46,"end":46,"feature_id":"monomer_feature_442","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":46,"original_end":46},{"begin":47,"end":47,"feature_id":"monomer_feature_443","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":47,"original_end":47},{"begin":48,"end":48,"feature_id":"monomer_feature_444","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":48,"original_end":48},{"begin":49,"end":49,"feature_id":"monomer_feature_445","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":49,"original_end":49},{"begin":50,"end":50,"feature_id":"monomer_feature_446","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":50,"original_end":50},{"begin":51,"end":51,"feature_id":"monomer_feature_447","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":51,"original_end":51},{"begin":52,"end":52,"feature_id":"monomer_feature_448","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":52,"original_end":52},{"begin":53,"end":53,"feature_id":"monomer_feature_449","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":54,"end":54,"feature_id":"monomer_feature_450","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":54,"original_end":54},{"begin":55,"end":55,"feature_id":"monomer_feature_451","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":55,"original_end":55},{"begin":56,"end":56,"feature_id":"monomer_feature_452","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":56,"original_end":56},{"begin":57,"end":57,"feature_id":"monomer_feature_453","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":57,"original_end":57},{"begin":58,"end":58,"feature_id":"monomer_feature_454","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":58,"original_end":58},{"begin":59,"end":59,"feature_id":"monomer_feature_455","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":59,"original_end":59},{"begin":60,"end":60,"feature_id":"monomer_feature_456","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":60,"original_end":60},{"begin":61,"end":61,"feature_id":"monomer_feature_457","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":61,"original_end":61},{"begin":62,"end":62,"feature_id":"monomer_feature_458","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_4","provenance_source":"PDB","original_begin":62,"original_end":62}]}]},{"instance_id":"4UIS.C","entity_id":"3","label_asym_id":"C","auth_asym_id":"C","description":"GAMMA-SECRETASE","polymer_type":"polypeptide(L)","sequence":{"value":"XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX","length":196},"alignments":[],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":2,"end":22,"feature_id":"HELX_P28","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":2,"original_end":22},{"begin":25,"end":34,"feature_id":"HELX_P29","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":25,"original_end":34},{"begin":35,"end":55,"feature_id":"HELX_P30","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":35,"original_end":55},{"begin":57,"end":87,"feature_id":"HELX_P31","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":57,"original_end":87},{"begin":89,"end":102,"feature_id":"HELX_P32","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":89,"original_end":102},{"begin":103,"end":115,"feature_id":"HELX_P33","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":103,"original_end":115},{"begin":126,"end":152,"feature_id":"HELX_P34","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":126,"original_end":152},{"begin":153,"end":158,"feature_id":"HELX_P35","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":153,"original_end":158},{"begin":158,"end":172,"feature_id":"HELX_P36","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":158,"original_end":172},{"begin":178,"end":194,"feature_id":"HELX_P37","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PROMOTIF","original_begin":178,"original_end":194}]},{"key":"cis_peptide","label":"CIS-PEPTIDE","kind":"point","features":[{"begin":119,"end":120,"feature_id":"5","type":"CIS_PEPTIDE","name":"cis-peptide","description":"cis-peptide bond in model 1 with omega angle 4.99","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDB","original_begin":119,"original_end":120}]},{"key":"buried_residues","label":"BURIED RESIDUES","kind":"point","features":[{"begin":1,"end":196,"feature_id":null,"type":"BURIED_RESIDUES","name":"Unbound chain core residues","description":"Residue accessibility lower than 6Å","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"NBDB derivation matching RCSB Saguaro App","original_begin":1,"original_end":null,"values":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.85,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":192,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":196,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.92,0.89,0.85,0.8,0.75,0.71,0.66,0.61,0.56,0.51,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.51,0.56,0.61,0.66,0.71,0.75,0.8,0.85,0.89,0.92]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":196,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15,0.15]}]},{"key":"other_membrane_segment","label":"MEMBRANE_SEGMENT","kind":"range","features":[{"begin":6,"end":21,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":6,"original_end":21},{"begin":8,"end":21,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":8,"original_end":21},{"begin":28,"end":44,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":28,"original_end":44},{"begin":43,"end":55,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":43,"original_end":55},{"begin":58,"end":83,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":58,"original_end":83},{"begin":68,"end":82,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":68,"original_end":82},{"begin":92,"end":116,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":92,"original_end":116},{"begin":94,"end":107,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":94,"original_end":107},{"begin":124,"end":128,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":124,"original_end":128},{"begin":129,"end":146,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":129,"original_end":146},{"begin":154,"end":167,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":154,"original_end":167},{"begin":154,"end":174,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":154,"original_end":174},{"begin":176,"end":193,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"OPM","original_begin":176,"original_end":193},{"begin":181,"end":194,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.C","provenance_source":"PDBTM","original_begin":181,"original_end":194}]},{"key":"other_modified_monomer","label":"MODIFIED_MONOMER","kind":"point","features":[{"begin":1,"end":1,"feature_id":"monomer_feature_201","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":1,"original_end":1},{"begin":2,"end":2,"feature_id":"monomer_feature_202","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":2,"original_end":2},{"begin":3,"end":3,"feature_id":"monomer_feature_203","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":3,"original_end":3},{"begin":4,"end":4,"feature_id":"monomer_feature_204","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":4,"original_end":4},{"begin":5,"end":5,"feature_id":"monomer_feature_205","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":5,"original_end":5},{"begin":6,"end":6,"feature_id":"monomer_feature_206","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":6,"original_end":6},{"begin":7,"end":7,"feature_id":"monomer_feature_207","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":7,"original_end":7},{"begin":8,"end":8,"feature_id":"monomer_feature_208","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":8,"original_end":8},{"begin":9,"end":9,"feature_id":"monomer_feature_209","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":9,"original_end":9},{"begin":10,"end":10,"feature_id":"monomer_feature_210","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":10,"original_end":10},{"begin":11,"end":11,"feature_id":"monomer_feature_211","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":11,"original_end":11},{"begin":12,"end":12,"feature_id":"monomer_feature_212","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":12,"original_end":12},{"begin":13,"end":13,"feature_id":"monomer_feature_213","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":13,"original_end":13},{"begin":14,"end":14,"feature_id":"monomer_feature_214","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":14,"original_end":14},{"begin":15,"end":15,"feature_id":"monomer_feature_215","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":15,"original_end":15},{"begin":16,"end":16,"feature_id":"monomer_feature_216","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":16,"original_end":16},{"begin":17,"end":17,"feature_id":"monomer_feature_217","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":17,"original_end":17},{"begin":18,"end":18,"feature_id":"monomer_feature_218","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":18,"original_end":18},{"begin":19,"end":19,"feature_id":"monomer_feature_219","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":19,"original_end":19},{"begin":20,"end":20,"feature_id":"monomer_feature_220","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":20,"original_end":20},{"begin":21,"end":21,"feature_id":"monomer_feature_221","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":21,"original_end":21},{"begin":22,"end":22,"feature_id":"monomer_feature_222","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":22,"original_end":22},{"begin":23,"end":23,"feature_id":"monomer_feature_223","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":23,"original_end":23},{"begin":24,"end":24,"feature_id":"monomer_feature_224","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":24,"original_end":24},{"begin":25,"end":25,"feature_id":"monomer_feature_225","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":25,"original_end":25},{"begin":26,"end":26,"feature_id":"monomer_feature_226","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":26,"original_end":26},{"begin":27,"end":27,"feature_id":"monomer_feature_227","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":27,"original_end":27},{"begin":28,"end":28,"feature_id":"monomer_feature_228","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":28,"original_end":28},{"begin":29,"end":29,"feature_id":"monomer_feature_229","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":29,"original_end":29},{"begin":30,"end":30,"feature_id":"monomer_feature_230","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":30,"original_end":30},{"begin":31,"end":31,"feature_id":"monomer_feature_231","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":31,"original_end":31},{"begin":32,"end":32,"feature_id":"monomer_feature_232","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":32,"original_end":32},{"begin":33,"end":33,"feature_id":"monomer_feature_233","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":33,"original_end":33},{"begin":34,"end":34,"feature_id":"monomer_feature_234","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":34,"original_end":34},{"begin":35,"end":35,"feature_id":"monomer_feature_235","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":35,"original_end":35},{"begin":36,"end":36,"feature_id":"monomer_feature_236","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":36,"original_end":36},{"begin":37,"end":37,"feature_id":"monomer_feature_237","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":37,"original_end":37},{"begin":38,"end":38,"feature_id":"monomer_feature_238","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":38,"original_end":38},{"begin":39,"end":39,"feature_id":"monomer_feature_239","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":39,"original_end":39},{"begin":40,"end":40,"feature_id":"monomer_feature_240","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":40,"original_end":40},{"begin":41,"end":41,"feature_id":"monomer_feature_241","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":41,"original_end":41},{"begin":42,"end":42,"feature_id":"monomer_feature_242","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":42,"original_end":42},{"begin":43,"end":43,"feature_id":"monomer_feature_243","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":43,"original_end":43},{"begin":44,"end":44,"feature_id":"monomer_feature_244","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":44,"original_end":44},{"begin":45,"end":45,"feature_id":"monomer_feature_245","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":45,"original_end":45},{"begin":46,"end":46,"feature_id":"monomer_feature_246","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":46,"original_end":46},{"begin":47,"end":47,"feature_id":"monomer_feature_247","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":47,"original_end":47},{"begin":48,"end":48,"feature_id":"monomer_feature_248","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":48,"original_end":48},{"begin":49,"end":49,"feature_id":"monomer_feature_249","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":49,"original_end":49},{"begin":50,"end":50,"feature_id":"monomer_feature_250","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":50,"original_end":50},{"begin":51,"end":51,"feature_id":"monomer_feature_251","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":51,"original_end":51},{"begin":52,"end":52,"feature_id":"monomer_feature_252","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":52,"original_end":52},{"begin":53,"end":53,"feature_id":"monomer_feature_253","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":54,"end":54,"feature_id":"monomer_feature_254","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":54,"original_end":54},{"begin":55,"end":55,"feature_id":"monomer_feature_255","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":55,"original_end":55},{"begin":56,"end":56,"feature_id":"monomer_feature_256","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":56,"original_end":56},{"begin":57,"end":57,"feature_id":"monomer_feature_257","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":57,"original_end":57},{"begin":58,"end":58,"feature_id":"monomer_feature_258","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":58,"original_end":58},{"begin":59,"end":59,"feature_id":"monomer_feature_259","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":59,"original_end":59},{"begin":60,"end":60,"feature_id":"monomer_feature_260","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":60,"original_end":60},{"begin":61,"end":61,"feature_id":"monomer_feature_261","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":61,"original_end":61},{"begin":62,"end":62,"feature_id":"monomer_feature_262","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":62,"original_end":62},{"begin":63,"end":63,"feature_id":"monomer_feature_263","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":63,"original_end":63},{"begin":64,"end":64,"feature_id":"monomer_feature_264","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":64,"original_end":64},{"begin":65,"end":65,"feature_id":"monomer_feature_265","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":65,"original_end":65},{"begin":66,"end":66,"feature_id":"monomer_feature_266","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":66,"original_end":66},{"begin":67,"end":67,"feature_id":"monomer_feature_267","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":67,"original_end":67},{"begin":68,"end":68,"feature_id":"monomer_feature_268","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":68,"original_end":68},{"begin":69,"end":69,"feature_id":"monomer_feature_269","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":69,"original_end":69},{"begin":70,"end":70,"feature_id":"monomer_feature_270","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":70,"original_end":70},{"begin":71,"end":71,"feature_id":"monomer_feature_271","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":71,"original_end":71},{"begin":72,"end":72,"feature_id":"monomer_feature_272","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":72,"original_end":72},{"begin":73,"end":73,"feature_id":"monomer_feature_273","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":73,"original_end":73},{"begin":74,"end":74,"feature_id":"monomer_feature_274","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":74,"original_end":74},{"begin":75,"end":75,"feature_id":"monomer_feature_275","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":75,"original_end":75},{"begin":76,"end":76,"feature_id":"monomer_feature_276","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":76,"original_end":76},{"begin":77,"end":77,"feature_id":"monomer_feature_277","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":"monomer_feature_278","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":78,"original_end":78},{"begin":79,"end":79,"feature_id":"monomer_feature_279","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":79,"original_end":79},{"begin":80,"end":80,"feature_id":"monomer_feature_280","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":80,"original_end":80},{"begin":81,"end":81,"feature_id":"monomer_feature_281","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":81,"original_end":81},{"begin":82,"end":82,"feature_id":"monomer_feature_282","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":82,"original_end":82},{"begin":83,"end":83,"feature_id":"monomer_feature_283","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":83,"original_end":83},{"begin":84,"end":84,"feature_id":"monomer_feature_284","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":84,"original_end":84},{"begin":85,"end":85,"feature_id":"monomer_feature_285","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":85,"original_end":85},{"begin":86,"end":86,"feature_id":"monomer_feature_286","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":86,"original_end":86},{"begin":87,"end":87,"feature_id":"monomer_feature_287","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":87,"original_end":87},{"begin":88,"end":88,"feature_id":"monomer_feature_288","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":88,"original_end":88},{"begin":89,"end":89,"feature_id":"monomer_feature_289","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":89,"original_end":89},{"begin":90,"end":90,"feature_id":"monomer_feature_290","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":90,"original_end":90},{"begin":91,"end":91,"feature_id":"monomer_feature_291","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":91,"original_end":91},{"begin":92,"end":92,"feature_id":"monomer_feature_292","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":92,"original_end":92},{"begin":93,"end":93,"feature_id":"monomer_feature_293","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":93,"original_end":93},{"begin":94,"end":94,"feature_id":"monomer_feature_294","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":94,"original_end":94},{"begin":95,"end":95,"feature_id":"monomer_feature_295","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":95,"original_end":95},{"begin":96,"end":96,"feature_id":"monomer_feature_296","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":96,"original_end":96},{"begin":97,"end":97,"feature_id":"monomer_feature_297","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":97,"original_end":97},{"begin":98,"end":98,"feature_id":"monomer_feature_298","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":98,"original_end":98},{"begin":99,"end":99,"feature_id":"monomer_feature_299","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":99,"original_end":99},{"begin":100,"end":100,"feature_id":"monomer_feature_300","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":100,"original_end":100},{"begin":101,"end":101,"feature_id":"monomer_feature_301","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":101,"original_end":101},{"begin":102,"end":102,"feature_id":"monomer_feature_302","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":102,"original_end":102},{"begin":103,"end":103,"feature_id":"monomer_feature_303","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":103,"original_end":103},{"begin":104,"end":104,"feature_id":"monomer_feature_304","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":104,"original_end":104},{"begin":105,"end":105,"feature_id":"monomer_feature_305","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":105,"original_end":105},{"begin":106,"end":106,"feature_id":"monomer_feature_306","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":106,"original_end":106},{"begin":107,"end":107,"feature_id":"monomer_feature_307","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":107,"original_end":107},{"begin":108,"end":108,"feature_id":"monomer_feature_308","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":108,"original_end":108},{"begin":109,"end":109,"feature_id":"monomer_feature_309","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":109,"original_end":109},{"begin":110,"end":110,"feature_id":"monomer_feature_310","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":110,"original_end":110},{"begin":111,"end":111,"feature_id":"monomer_feature_311","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":111,"original_end":111},{"begin":112,"end":112,"feature_id":"monomer_feature_312","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":112,"original_end":112},{"begin":113,"end":113,"feature_id":"monomer_feature_313","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":113,"original_end":113},{"begin":114,"end":114,"feature_id":"monomer_feature_314","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":114,"original_end":114},{"begin":115,"end":115,"feature_id":"monomer_feature_315","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":115,"original_end":115},{"begin":116,"end":116,"feature_id":"monomer_feature_316","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":116,"original_end":116},{"begin":117,"end":117,"feature_id":"monomer_feature_317","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":117,"original_end":117},{"begin":118,"end":118,"feature_id":"monomer_feature_318","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":118,"original_end":118},{"begin":119,"end":119,"feature_id":"monomer_feature_319","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":119,"original_end":119},{"begin":120,"end":120,"feature_id":"monomer_feature_320","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":120,"original_end":120},{"begin":121,"end":121,"feature_id":"monomer_feature_321","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":121,"original_end":121},{"begin":122,"end":122,"feature_id":"monomer_feature_322","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":122,"original_end":122},{"begin":123,"end":123,"feature_id":"monomer_feature_323","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":123,"original_end":123},{"begin":124,"end":124,"feature_id":"monomer_feature_324","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":124,"original_end":124},{"begin":125,"end":125,"feature_id":"monomer_feature_325","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":125,"original_end":125},{"begin":126,"end":126,"feature_id":"monomer_feature_326","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":126,"original_end":126},{"begin":127,"end":127,"feature_id":"monomer_feature_327","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":127,"original_end":127},{"begin":128,"end":128,"feature_id":"monomer_feature_328","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":128,"original_end":128},{"begin":129,"end":129,"feature_id":"monomer_feature_329","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":129,"original_end":129},{"begin":130,"end":130,"feature_id":"monomer_feature_330","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":130,"original_end":130},{"begin":131,"end":131,"feature_id":"monomer_feature_331","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":131,"original_end":131},{"begin":132,"end":132,"feature_id":"monomer_feature_332","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":132,"original_end":132},{"begin":133,"end":133,"feature_id":"monomer_feature_333","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":133,"original_end":133},{"begin":134,"end":134,"feature_id":"monomer_feature_334","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":134,"original_end":134},{"begin":135,"end":135,"feature_id":"monomer_feature_335","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":135,"original_end":135},{"begin":136,"end":136,"feature_id":"monomer_feature_336","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":136,"original_end":136},{"begin":137,"end":137,"feature_id":"monomer_feature_337","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":137,"original_end":137},{"begin":138,"end":138,"feature_id":"monomer_feature_338","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":138,"original_end":138},{"begin":139,"end":139,"feature_id":"monomer_feature_339","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":139,"original_end":139},{"begin":140,"end":140,"feature_id":"monomer_feature_340","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":140,"original_end":140},{"begin":141,"end":141,"feature_id":"monomer_feature_341","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":141,"original_end":141},{"begin":142,"end":142,"feature_id":"monomer_feature_342","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":142,"original_end":142},{"begin":143,"end":143,"feature_id":"monomer_feature_343","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":143,"original_end":143},{"begin":144,"end":144,"feature_id":"monomer_feature_344","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":144,"original_end":144},{"begin":145,"end":145,"feature_id":"monomer_feature_345","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":145,"original_end":145},{"begin":146,"end":146,"feature_id":"monomer_feature_346","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":146,"original_end":146},{"begin":147,"end":147,"feature_id":"monomer_feature_347","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":147,"original_end":147},{"begin":148,"end":148,"feature_id":"monomer_feature_348","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":148,"original_end":148},{"begin":149,"end":149,"feature_id":"monomer_feature_349","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":149,"original_end":149},{"begin":150,"end":150,"feature_id":"monomer_feature_350","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":150,"original_end":150},{"begin":151,"end":151,"feature_id":"monomer_feature_351","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":151,"original_end":151},{"begin":152,"end":152,"feature_id":"monomer_feature_352","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":152,"original_end":152},{"begin":153,"end":153,"feature_id":"monomer_feature_353","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":153,"original_end":153},{"begin":154,"end":154,"feature_id":"monomer_feature_354","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":154,"original_end":154},{"begin":155,"end":155,"feature_id":"monomer_feature_355","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":155,"original_end":155},{"begin":156,"end":156,"feature_id":"monomer_feature_356","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":156,"original_end":156},{"begin":157,"end":157,"feature_id":"monomer_feature_357","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":157,"original_end":157},{"begin":158,"end":158,"feature_id":"monomer_feature_358","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":158,"original_end":158},{"begin":159,"end":159,"feature_id":"monomer_feature_359","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":159,"original_end":159},{"begin":160,"end":160,"feature_id":"monomer_feature_360","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":160,"original_end":160},{"begin":161,"end":161,"feature_id":"monomer_feature_361","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":161,"original_end":161},{"begin":162,"end":162,"feature_id":"monomer_feature_362","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":162,"original_end":162},{"begin":163,"end":163,"feature_id":"monomer_feature_363","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":163,"original_end":163},{"begin":164,"end":164,"feature_id":"monomer_feature_364","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":164,"original_end":164},{"begin":165,"end":165,"feature_id":"monomer_feature_365","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":165,"original_end":165},{"begin":166,"end":166,"feature_id":"monomer_feature_366","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":166,"original_end":166},{"begin":167,"end":167,"feature_id":"monomer_feature_367","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":167,"original_end":167},{"begin":168,"end":168,"feature_id":"monomer_feature_368","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":168,"original_end":168},{"begin":169,"end":169,"feature_id":"monomer_feature_369","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":169,"original_end":169},{"begin":170,"end":170,"feature_id":"monomer_feature_370","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":170,"original_end":170},{"begin":171,"end":171,"feature_id":"monomer_feature_371","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":171,"original_end":171},{"begin":172,"end":172,"feature_id":"monomer_feature_372","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":172,"original_end":172},{"begin":173,"end":173,"feature_id":"monomer_feature_373","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":173,"original_end":173},{"begin":174,"end":174,"feature_id":"monomer_feature_374","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":174,"original_end":174},{"begin":175,"end":175,"feature_id":"monomer_feature_375","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":175,"original_end":175},{"begin":176,"end":176,"feature_id":"monomer_feature_376","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":176,"original_end":176},{"begin":177,"end":177,"feature_id":"monomer_feature_377","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":177,"original_end":177},{"begin":178,"end":178,"feature_id":"monomer_feature_378","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":178,"original_end":178},{"begin":179,"end":179,"feature_id":"monomer_feature_379","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":179,"original_end":179},{"begin":180,"end":180,"feature_id":"monomer_feature_380","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":180,"original_end":180},{"begin":181,"end":181,"feature_id":"monomer_feature_381","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":181,"original_end":181},{"begin":182,"end":182,"feature_id":"monomer_feature_382","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":182,"original_end":182},{"begin":183,"end":183,"feature_id":"monomer_feature_383","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":183,"original_end":183},{"begin":184,"end":184,"feature_id":"monomer_feature_384","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":184,"original_end":184},{"begin":185,"end":185,"feature_id":"monomer_feature_385","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":185,"original_end":185},{"begin":186,"end":186,"feature_id":"monomer_feature_386","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":186,"original_end":186},{"begin":187,"end":187,"feature_id":"monomer_feature_387","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":187,"original_end":187},{"begin":188,"end":188,"feature_id":"monomer_feature_388","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":188,"original_end":188},{"begin":189,"end":189,"feature_id":"monomer_feature_389","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":189,"original_end":189},{"begin":190,"end":190,"feature_id":"monomer_feature_390","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":190,"original_end":190},{"begin":191,"end":191,"feature_id":"monomer_feature_391","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":191,"original_end":191},{"begin":192,"end":192,"feature_id":"monomer_feature_392","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":192,"original_end":192},{"begin":193,"end":193,"feature_id":"monomer_feature_393","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":193,"original_end":193},{"begin":194,"end":194,"feature_id":"monomer_feature_394","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":194,"original_end":194},{"begin":195,"end":195,"feature_id":"monomer_feature_395","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":195,"original_end":195},{"begin":196,"end":196,"feature_id":"monomer_feature_396","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_3","provenance_source":"PDB","original_begin":196,"original_end":196}]}]},{"instance_id":"4UIS.B","entity_id":"2","label_asym_id":"B","auth_asym_id":"B","description":"GAMMA-SECRETASE","polymer_type":"polypeptide(L)","sequence":{"value":"XXXXXXXXXXXXHVIMLFVPVTLCMVVVVATIXXXXXXXXXXXXXXXXXXXXXXXXXXXLLLFFFSFIYLGEVFKTYXXXXXXXXXXLIWNFGXXXXXXXXXXXXXRLQQAYLIMISALMXXXXXXXXXXXXXXXXXXXXDXXXXXXXXXXXXXXXXXXXXDXXXXXXXXXXXXXXXXXXWNTTIACFVAILIGLCLTLLXXXXXXXXXXXXXXXXXGLVFYFATDYLVQPFADQLAFHXX","length":241},"alignments":[{"source":"UNIPROT","target_id":"P49768","target_sequence":"MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI","query_coverage":0.24481327800829875,"query_length":241,"target_coverage":0.12633832976445397,"target_length":467,"orientation":null,"regions":[{"query_begin":181,"query_end":239,"target_begin":404,"target_end":462,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":1,"end":33,"feature_id":"HELX_P18","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":1,"original_end":33},{"begin":36,"end":54,"feature_id":"HELX_P19","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":36,"original_end":54},{"begin":55,"end":78,"feature_id":"HELX_P20","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":55,"original_end":78},{"begin":81,"end":103,"feature_id":"HELX_P21","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":81,"original_end":103},{"begin":105,"end":128,"feature_id":"HELX_P22","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":105,"original_end":128},{"begin":130,"end":155,"feature_id":"HELX_P23","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":130,"original_end":155},{"begin":159,"end":177,"feature_id":"HELX_P24","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":159,"original_end":177},{"begin":181,"end":204,"feature_id":"HELX_P25","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":181,"original_end":204},{"begin":210,"end":228,"feature_id":"HELX_P26","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":210,"original_end":228},{"begin":228,"end":239,"feature_id":"HELX_P27","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PROMOTIF","original_begin":228,"original_end":239}]},{"key":"buried_residues","label":"BURIED RESIDUES","kind":"point","features":[{"begin":1,"end":241,"feature_id":null,"type":"BURIED_RESIDUES","name":"Unbound chain core residues","description":"Residue accessibility lower than 6Å","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"NBDB derivation matching RCSB Saguaro App","original_begin":1,"original_end":null,"values":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.67,0,0,0,2.41,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.98,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.3,0,0,4.9,0,0,4.94,0,0,0,0,0,0,2.88,0,0,0,0,0,0,4.81,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.91,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":237,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.0,0.0,0.0,0.0,-3.2,0.5,1.83,1.85,2.24,2.33,2.6,2.07,2.31,2.59,2.54,2.32,2.32,2.37,2.52,2.52,3.17,2.9,2.9,2.98,3.04,3.2,3.03,2.8,2.45,1.87,1.9,4.5,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,3.8,3.8,3.8,3.55,3.4,3.3,2.71,2.73,2.92,2.36,2.36,1.89,1.19,1.34,1.34,1.0,0.61,-0.03,0.12,-0.4,-0.4,0.22,-0.77,-1.97,-1.0,-1.3,0.0,0.0,3.8,4.15,2.47,0.98,1.34,1.05,1.05,1.05,1.05,0.5,-0.5,-0.37,1.2,-0.4,0.0,0.0,0.0,0.0,0.0,-4.5,-0.35,-1.4,-1.92,-1.18,-1.2,-0.49,0.14,0.33,1.33,0.82,1.41,2.22,2.23,2.68,2.51,2.18,2.24,1.67,2.5,2.85,1.9,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,-3.5,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,-0.9,-2.2,-1.7,-1.45,-0.26,0.08,0.43,0.72,1.11,1.41,2.3,2.8,3.38,2.83,3.06,3.06,3.17,2.62,2.84,2.77,2.64,2.37,2.83,2.64,2.68,2.3,3.8,3.8,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,-0.4,1.7,2.53,2.6,1.82,1.98,1.96,1.63,1.06,0.96,0.96,0.96,0.26,0.22,0.22,0.22,-0.09,-0.09,0.48,0.26,0.1,0.13,0.35,0.0]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":241,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.92,0.89,0.85,0.76,0.66,0.58,0.48,0.37,0.27,0.23,0.15,0.15,0.11,0.1,0.09,0.07,0.06,0.05,0.04,0.03,0.03,0.02,0.02,0.02,0.03,0.05,0.05,0.08,0.11,0.14,0.13,0.17,0.16,0.21,0.23,0.25,0.29,0.32,0.35,0.39,0.41,0.41,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.41,0.37,0.32,0.27,0.22,0.17,0.17,0.12,0.09,0.06,0.04,0.04,0.04,0.03,0.02,0.02,0.02,0.01,0.01,0.01,0.01,0.02,0.02,0.03,0.04,0.06,0.09,0.09,0.09,0.09,0.08,0.13,0.09,0.08,0.11,0.16,0.16,0.16,0.21,0.21,0.21,0.21,0.21,0.21,0.21,0.21,0.21,0.21,0.17,0.23,0.3,0.34,0.29,0.32,0.28,0.27,0.23,0.23,0.22,0.2,0.19,0.19,0.19,0.19,0.19,0.19,0.19,0.19,0.18,0.23,0.23,0.23,0.24,0.28,0.33,0.36,0.38,0.41,0.41,0.42,0.45,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.43,0.43,0.43,0.43,0.38,0.37,0.32,0.28,0.25,0.23,0.19,0.16,0.12,0.12,0.09,0.06,0.04,0.04,0.03,0.01,0.01,0.02,0.02,0.02,0.02,0.03,0.03,0.04,0.05,0.06,0.07,0.09,0.12,0.15,0.15,0.2,0.24,0.31,0.25,0.27,0.27,0.23,0.17,0.15,0.15,0.16,0.13,0.09,0.07,0.07,0.09,0.05,0.05,0.05,0.05,0.03,0.03,0.02,0.01,0.02,0.03,0.07,0.13,0.23,0.31,0.36,0.4,0.5,0.6,0.69,0.73]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":241,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.16,0.16,0.16,0.17,0.18,0.2,0.24,0.29,0.36,0.42,0.38,0.33,0.28,0.23,0.2,0.18,0.17,0.17,0.19,0.21,0.22,0.24,0.25,0.27,0.3,0.33,0.37,0.4,0.43,0.41,0.38,0.36,0.33,0.29,0.26,0.25,0.23,0.22,0.22,0.21,0.21,0.21,0.2,0.2,0.2,0.21,0.21,0.21,0.22,0.23,0.24,0.26,0.28,0.31,0.36,0.4,0.42,0.37,0.33,0.28,0.25,0.23,0.21,0.2,0.2,0.21,0.21,0.22,0.23,0.25,0.27,0.3,0.32,0.34,0.37,0.4,0.43,0.4,0.38,0.36,0.35,0.35,0.36,0.36,0.36,0.38,0.39,0.41,0.42,0.43,0.41,0.4,0.38,0.36,0.34,0.33,0.32,0.32,0.31,0.31,0.32,0.34,0.36,0.38,0.41,0.43,0.42,0.41,0.4,0.4,0.4,0.41,0.42,0.44,0.45,0.47,0.48,0.49,0.49,0.48,0.48,0.46,0.44,0.42,0.41,0.39,0.38,0.36,0.35,0.33,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.44,0.38,0.39,0.4,0.41,0.41,0.42,0.43,0.43,0.43,0.44,0.44,0.43,0.43,0.42,0.41,0.39,0.38,0.36,0.34,0.33,0.31,0.3,0.3,0.29,0.3,0.31,0.32,0.35,0.37,0.4,0.42,0.38,0.35,0.31,0.29,0.26,0.24,0.22,0.21,0.2,0.2,0.2,0.21,0.21,0.22,0.22,0.23,0.24,0.24,0.25,0.26,0.26,0.25,0.25,0.24,0.24,0.24,0.24,0.24,0.24,0.24,0.24,0.24,0.25,0.26,0.27,0.27,0.27,0.26,0.26,0.27]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":1,"end":241,"feature_id":"e4uisB1","type":"ECOD","name":"WD40, Beta-prop_NOL10_N","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"ECOD","original_begin":1,"original_end":241}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":181,"end":239,"feature_id":"PRO_0000025592","type":"CHAIN","name":null,"description":"Presenilin-1 CTF subunit","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":462},{"begin":181,"end":239,"feature_id":"PRO_0000236055","type":"CHAIN","name":null,"description":"Presenilin-1 CTF12","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":462}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":189,"end":189,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes protease activity with APP.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":412,"original_end":412},{"begin":197,"end":197,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Decreased protease activity with APP. Increased amyloid-beta 42/amyloid-beta 40 ratio in vitro.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":420,"original_end":420},{"begin":201,"end":201,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases protease activity with APP.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":424,"original_end":424},{"begin":209,"end":209,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Loss of NOTCH1 and APP C83 cleavage.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":432,"original_end":432},{"begin":209,"end":211,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Loss of NOTCH1 and APP C83 cleavage.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":432,"original_end":434},{"begin":210,"end":210,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No endoproteolytic cleavage; no APP, nor NOTCH1 processing. No detectable amyloid-beta.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":433,"original_end":433},{"begin":210,"end":210,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing. Slightly increased amyloid-beta protein 42/40 ratio.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":433,"original_end":433},{"begin":210,"end":210,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Very little endoproteolysis. Little APP processing. No NOTCH1 processing. Very low levels amyloid-beta protein 40 and no detectable amyloid-beta protein 42.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":433,"original_end":433},{"begin":211,"end":211,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Some loss of endoproteolytic cleavage. Some loss of APP and NOTCH1 processing. 6 to 13-fold increase in amyloid-beta protein 42/40 ratio.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":434,"original_end":434},{"begin":211,"end":211,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing. Reduced amyloid-beta protein 42/40 ratio.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":434,"original_end":434},{"begin":211,"end":211,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable amyloid-beta.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":434,"original_end":434},{"begin":212,"end":212,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Greatly reduced endoproteolytic cleavage. Very little APP and NOTCH1 processing. Very low levels of amyloid-beta protein 40 and no detectable amyloid-beta protein 42.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":212,"end":212,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Greatly reduced amyloid-beta protein 42/40 ratio.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":212,"end":212,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Some increase in amyloid-beta protein 42/40 ratio.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":212,"end":212,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No endoproteolytic cleavage; no APP, nor NOTCH1 processing. No detectable amyloid-beta.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":212,"end":212,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":214,"end":214,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Decreased protease activity with APP. Increased amyloid-beta 42/amyloid-beta 40 ratio in vitro.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":437,"original_end":437}]},{"key":"other_membrane_segment","label":"MEMBRANE_SEGMENT","kind":"range","features":[{"begin":12,"end":32,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":12,"original_end":32},{"begin":17,"end":31,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":17,"original_end":31},{"begin":38,"end":51,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":38,"original_end":51},{"begin":49,"end":53,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":49,"original_end":53},{"begin":54,"end":66,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":54,"original_end":66},{"begin":55,"end":76,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":55,"original_end":76},{"begin":81,"end":101,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":81,"original_end":101},{"begin":83,"end":99,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":83,"original_end":99},{"begin":107,"end":123,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":107,"original_end":123},{"begin":107,"end":127,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":107,"original_end":127},{"begin":130,"end":152,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":130,"original_end":152},{"begin":133,"end":146,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":133,"original_end":146},{"begin":157,"end":169,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":157,"original_end":169},{"begin":158,"end":175,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":158,"original_end":175},{"begin":180,"end":200,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":180,"original_end":200},{"begin":183,"end":197,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":183,"original_end":197},{"begin":208,"end":221,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"PDBTM","original_begin":208,"original_end":221},{"begin":209,"end":228,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.B","provenance_source":"OPM","original_begin":209,"original_end":228}]},{"key":"other_modified_monomer","label":"MODIFIED_MONOMER","kind":"point","features":[{"begin":1,"end":1,"feature_id":"monomer_feature_62","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":1,"original_end":1},{"begin":2,"end":2,"feature_id":"monomer_feature_63","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":2,"original_end":2},{"begin":3,"end":3,"feature_id":"monomer_feature_64","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":3,"original_end":3},{"begin":4,"end":4,"feature_id":"monomer_feature_65","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":4,"original_end":4},{"begin":5,"end":5,"feature_id":"monomer_feature_66","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":5,"original_end":5},{"begin":6,"end":6,"feature_id":"monomer_feature_67","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":6,"original_end":6},{"begin":7,"end":7,"feature_id":"monomer_feature_68","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":7,"original_end":7},{"begin":8,"end":8,"feature_id":"monomer_feature_69","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":8,"original_end":8},{"begin":9,"end":9,"feature_id":"monomer_feature_70","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":9,"original_end":9},{"begin":10,"end":10,"feature_id":"monomer_feature_71","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":10,"original_end":10},{"begin":11,"end":11,"feature_id":"monomer_feature_72","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":11,"original_end":11},{"begin":12,"end":12,"feature_id":"monomer_feature_73","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":12,"original_end":12},{"begin":33,"end":33,"feature_id":"monomer_feature_74","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":33,"original_end":33},{"begin":34,"end":34,"feature_id":"monomer_feature_75","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":34,"original_end":34},{"begin":35,"end":35,"feature_id":"monomer_feature_76","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":35,"original_end":35},{"begin":36,"end":36,"feature_id":"monomer_feature_77","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":36,"original_end":36},{"begin":37,"end":37,"feature_id":"monomer_feature_78","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":37,"original_end":37},{"begin":38,"end":38,"feature_id":"monomer_feature_79","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":38,"original_end":38},{"begin":39,"end":39,"feature_id":"monomer_feature_80","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":39,"original_end":39},{"begin":40,"end":40,"feature_id":"monomer_feature_81","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":40,"original_end":40},{"begin":41,"end":41,"feature_id":"monomer_feature_82","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":41,"original_end":41},{"begin":42,"end":42,"feature_id":"monomer_feature_83","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":42,"original_end":42},{"begin":43,"end":43,"feature_id":"monomer_feature_84","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":43,"original_end":43},{"begin":44,"end":44,"feature_id":"monomer_feature_85","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":44,"original_end":44},{"begin":45,"end":45,"feature_id":"monomer_feature_86","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":45,"original_end":45},{"begin":46,"end":46,"feature_id":"monomer_feature_87","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":46,"original_end":46},{"begin":47,"end":47,"feature_id":"monomer_feature_88","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":47,"original_end":47},{"begin":48,"end":48,"feature_id":"monomer_feature_89","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":48,"original_end":48},{"begin":49,"end":49,"feature_id":"monomer_feature_90","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":49,"original_end":49},{"begin":50,"end":50,"feature_id":"monomer_feature_91","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":50,"original_end":50},{"begin":51,"end":51,"feature_id":"monomer_feature_92","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":51,"original_end":51},{"begin":52,"end":52,"feature_id":"monomer_feature_93","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":52,"original_end":52},{"begin":53,"end":53,"feature_id":"monomer_feature_94","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":54,"end":54,"feature_id":"monomer_feature_95","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":54,"original_end":54},{"begin":55,"end":55,"feature_id":"monomer_feature_96","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":55,"original_end":55},{"begin":56,"end":56,"feature_id":"monomer_feature_97","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":56,"original_end":56},{"begin":57,"end":57,"feature_id":"monomer_feature_98","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":57,"original_end":57},{"begin":58,"end":58,"feature_id":"monomer_feature_99","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":58,"original_end":58},{"begin":59,"end":59,"feature_id":"monomer_feature_100","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":59,"original_end":59},{"begin":78,"end":78,"feature_id":"monomer_feature_101","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":78,"original_end":78},{"begin":79,"end":79,"feature_id":"monomer_feature_102","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":79,"original_end":79},{"begin":80,"end":80,"feature_id":"monomer_feature_103","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":80,"original_end":80},{"begin":81,"end":81,"feature_id":"monomer_feature_104","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":81,"original_end":81},{"begin":82,"end":82,"feature_id":"monomer_feature_105","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":82,"original_end":82},{"begin":83,"end":83,"feature_id":"monomer_feature_106","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":83,"original_end":83},{"begin":84,"end":84,"feature_id":"monomer_feature_107","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":84,"original_end":84},{"begin":85,"end":85,"feature_id":"monomer_feature_108","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":85,"original_end":85},{"begin":86,"end":86,"feature_id":"monomer_feature_109","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":86,"original_end":86},{"begin":87,"end":87,"feature_id":"monomer_feature_110","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":87,"original_end":87},{"begin":94,"end":94,"feature_id":"monomer_feature_111","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":94,"original_end":94},{"begin":95,"end":95,"feature_id":"monomer_feature_112","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":95,"original_end":95},{"begin":96,"end":96,"feature_id":"monomer_feature_113","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":96,"original_end":96},{"begin":97,"end":97,"feature_id":"monomer_feature_114","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":97,"original_end":97},{"begin":98,"end":98,"feature_id":"monomer_feature_115","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":98,"original_end":98},{"begin":99,"end":99,"feature_id":"monomer_feature_116","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":99,"original_end":99},{"begin":100,"end":100,"feature_id":"monomer_feature_117","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":100,"original_end":100},{"begin":101,"end":101,"feature_id":"monomer_feature_118","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":101,"original_end":101},{"begin":102,"end":102,"feature_id":"monomer_feature_119","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":102,"original_end":102},{"begin":103,"end":103,"feature_id":"monomer_feature_120","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":103,"original_end":103},{"begin":104,"end":104,"feature_id":"monomer_feature_121","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":104,"original_end":104},{"begin":105,"end":105,"feature_id":"monomer_feature_122","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":105,"original_end":105},{"begin":106,"end":106,"feature_id":"monomer_feature_123","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":106,"original_end":106},{"begin":121,"end":121,"feature_id":"monomer_feature_124","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":121,"original_end":121},{"begin":122,"end":122,"feature_id":"monomer_feature_125","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":122,"original_end":122},{"begin":123,"end":123,"feature_id":"monomer_feature_126","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":123,"original_end":123},{"begin":124,"end":124,"feature_id":"monomer_feature_127","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":124,"original_end":124},{"begin":125,"end":125,"feature_id":"monomer_feature_128","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":125,"original_end":125},{"begin":126,"end":126,"feature_id":"monomer_feature_129","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":126,"original_end":126},{"begin":127,"end":127,"feature_id":"monomer_feature_130","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":127,"original_end":127},{"begin":128,"end":128,"feature_id":"monomer_feature_131","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":128,"original_end":128},{"begin":129,"end":129,"feature_id":"monomer_feature_132","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":129,"original_end":129},{"begin":130,"end":130,"feature_id":"monomer_feature_133","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":130,"original_end":130},{"begin":131,"end":131,"feature_id":"monomer_feature_134","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":131,"original_end":131},{"begin":132,"end":132,"feature_id":"monomer_feature_135","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":132,"original_end":132},{"begin":133,"end":133,"feature_id":"monomer_feature_136","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":133,"original_end":133},{"begin":134,"end":134,"feature_id":"monomer_feature_137","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":134,"original_end":134},{"begin":135,"end":135,"feature_id":"monomer_feature_138","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":135,"original_end":135},{"begin":136,"end":136,"feature_id":"monomer_feature_139","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":136,"original_end":136},{"begin":137,"end":137,"feature_id":"monomer_feature_140","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":137,"original_end":137},{"begin":138,"end":138,"feature_id":"monomer_feature_141","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":138,"original_end":138},{"begin":139,"end":139,"feature_id":"monomer_feature_142","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":139,"original_end":139},{"begin":140,"end":140,"feature_id":"monomer_feature_143","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":140,"original_end":140},{"begin":142,"end":142,"feature_id":"monomer_feature_144","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":142,"original_end":142},{"begin":143,"end":143,"feature_id":"monomer_feature_145","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":143,"original_end":143},{"begin":144,"end":144,"feature_id":"monomer_feature_146","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":144,"original_end":144},{"begin":145,"end":145,"feature_id":"monomer_feature_147","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":145,"original_end":145},{"begin":146,"end":146,"feature_id":"monomer_feature_148","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":146,"original_end":146},{"begin":147,"end":147,"feature_id":"monomer_feature_149","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":147,"original_end":147},{"begin":148,"end":148,"feature_id":"monomer_feature_150","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":148,"original_end":148},{"begin":149,"end":149,"feature_id":"monomer_feature_151","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":149,"original_end":149},{"begin":150,"end":150,"feature_id":"monomer_feature_152","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":150,"original_end":150},{"begin":151,"end":151,"feature_id":"monomer_feature_153","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":151,"original_end":151},{"begin":152,"end":152,"feature_id":"monomer_feature_154","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":152,"original_end":152},{"begin":153,"end":153,"feature_id":"monomer_feature_155","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":153,"original_end":153},{"begin":154,"end":154,"feature_id":"monomer_feature_156","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":154,"original_end":154},{"begin":155,"end":155,"feature_id":"monomer_feature_157","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":155,"original_end":155},{"begin":156,"end":156,"feature_id":"monomer_feature_158","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":156,"original_end":156},{"begin":157,"end":157,"feature_id":"monomer_feature_159","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":157,"original_end":157},{"begin":158,"end":158,"feature_id":"monomer_feature_160","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":158,"original_end":158},{"begin":159,"end":159,"feature_id":"monomer_feature_161","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":159,"original_end":159},{"begin":160,"end":160,"feature_id":"monomer_feature_162","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":160,"original_end":160},{"begin":161,"end":161,"feature_id":"monomer_feature_163","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":161,"original_end":161},{"begin":163,"end":163,"feature_id":"monomer_feature_164","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":163,"original_end":163},{"begin":164,"end":164,"feature_id":"monomer_feature_165","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":164,"original_end":164},{"begin":165,"end":165,"feature_id":"monomer_feature_166","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":165,"original_end":165},{"begin":166,"end":166,"feature_id":"monomer_feature_167","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":166,"original_end":166},{"begin":167,"end":167,"feature_id":"monomer_feature_168","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":167,"original_end":167},{"begin":168,"end":168,"feature_id":"monomer_feature_169","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":168,"original_end":168},{"begin":169,"end":169,"feature_id":"monomer_feature_170","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":169,"original_end":169},{"begin":170,"end":170,"feature_id":"monomer_feature_171","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":170,"original_end":170},{"begin":171,"end":171,"feature_id":"monomer_feature_172","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":171,"original_end":171},{"begin":172,"end":172,"feature_id":"monomer_feature_173","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":172,"original_end":172},{"begin":173,"end":173,"feature_id":"monomer_feature_174","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":173,"original_end":173},{"begin":174,"end":174,"feature_id":"monomer_feature_175","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":174,"original_end":174},{"begin":175,"end":175,"feature_id":"monomer_feature_176","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":175,"original_end":175},{"begin":176,"end":176,"feature_id":"monomer_feature_177","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":176,"original_end":176},{"begin":177,"end":177,"feature_id":"monomer_feature_178","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":177,"original_end":177},{"begin":178,"end":178,"feature_id":"monomer_feature_179","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":178,"original_end":178},{"begin":179,"end":179,"feature_id":"monomer_feature_180","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":179,"original_end":179},{"begin":180,"end":180,"feature_id":"monomer_feature_181","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":180,"original_end":180},{"begin":201,"end":201,"feature_id":"monomer_feature_182","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":201,"original_end":201},{"begin":202,"end":202,"feature_id":"monomer_feature_183","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":202,"original_end":202},{"begin":203,"end":203,"feature_id":"monomer_feature_184","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":203,"original_end":203},{"begin":204,"end":204,"feature_id":"monomer_feature_185","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":204,"original_end":204},{"begin":205,"end":205,"feature_id":"monomer_feature_186","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":205,"original_end":205},{"begin":206,"end":206,"feature_id":"monomer_feature_187","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":206,"original_end":206},{"begin":207,"end":207,"feature_id":"monomer_feature_188","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":207,"original_end":207},{"begin":208,"end":208,"feature_id":"monomer_feature_189","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":208,"original_end":208},{"begin":209,"end":209,"feature_id":"monomer_feature_190","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":209,"original_end":209},{"begin":210,"end":210,"feature_id":"monomer_feature_191","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":210,"original_end":210},{"begin":211,"end":211,"feature_id":"monomer_feature_192","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":211,"original_end":211},{"begin":212,"end":212,"feature_id":"monomer_feature_193","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":212,"original_end":212},{"begin":213,"end":213,"feature_id":"monomer_feature_194","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":213,"original_end":213},{"begin":214,"end":214,"feature_id":"monomer_feature_195","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":214,"original_end":214},{"begin":215,"end":215,"feature_id":"monomer_feature_196","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":215,"original_end":215},{"begin":216,"end":216,"feature_id":"monomer_feature_197","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":216,"original_end":216},{"begin":217,"end":217,"feature_id":"monomer_feature_198","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":217,"original_end":217},{"begin":240,"end":240,"feature_id":"monomer_feature_199","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":240,"original_end":240},{"begin":241,"end":241,"feature_id":"monomer_feature_200","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_2","provenance_source":"PDB","original_begin":241,"original_end":241}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":181,"end":227,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Required for interaction with CTNNB1","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":450},{"begin":209,"end":211,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Important for cleavage of target proteins","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":432,"original_end":434}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":182,"end":182,"feature_id":"VAR_010129","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance; decreased protease activity with APP; dbSNP:rs63751254.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":405,"original_end":405},{"begin":185,"end":185,"feature_id":"VAR_075277","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; dbSNP:rs906454643.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":408,"original_end":408},{"begin":186,"end":186,"feature_id":"VAR_009213","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance; decreased protease activity with APP; dbSNP:rs63750227.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":409,"original_end":409},{"begin":187,"end":187,"feature_id":"VAR_006458","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; results in reduced APP and Notch proteolysis; dbSNP:rs661.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":410,"original_end":410},{"begin":194,"end":194,"feature_id":"VAR_081259","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":417,"original_end":417},{"begin":195,"end":195,"feature_id":"VAR_075278","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance; nearly abolishes protease activity with APP; dbSNP:rs63751316.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":418,"original_end":418},{"begin":203,"end":203,"feature_id":"VAR_006459","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance; slightly decreased protease activity with APP; dbSNP:rs63751223.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":426,"original_end":426},{"begin":208,"end":208,"feature_id":"VAR_025605","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; decreased protease activity with APP; results in altered amyloid-beta production and increased amyloid-beta 42/amyloid-beta 40 ratio; dbSNP:rs63750083.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":431,"original_end":431},{"begin":212,"end":212,"feature_id":"VAR_075280","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; with unusual amyloid cotton wool plaques; almost abolishes gamma-secretase activity; no endoproteolytic cleavage; no APP nor NOTCH1 processing; no detectable amyloid-beta; dbSNP:rs63750001.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":435,"original_end":435},{"begin":213,"end":213,"feature_id":"VAR_006460","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; severe decrease of protease activity with APP; dbSNP:rs121917808.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":436,"original_end":436},{"begin":213,"end":213,"feature_id":"VAR_008141","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; partially abolishes gamma-secretase activity; results in altered amyloid-beta production and increased amyloid-beta 42/amyloid-beta 40 ratio; dbSNP:rs63749925.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":436,"original_end":436},{"begin":216,"end":216,"feature_id":"VAR_075282","type":"SEQUENCE_VARIANT","name":null,"description":"In AD3; uncertain significance; no significant change of protease activity with APP; dbSNP:rs63750249.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":439,"original_end":439}]},{"key":"other_short_sequence_motif","label":"SHORT_SEQUENCE_MOTIF","kind":"range","features":[{"begin":210,"end":212,"feature_id":null,"type":"SHORT_SEQUENCE_MOTIF","name":null,"description":"PAL","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":433,"original_end":435}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":181,"end":239,"feature_id":"VSP_007987","type":"SPLICE_VARIANT","name":null,"description":"In isoform 4.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":462},{"begin":181,"end":239,"feature_id":"VSP_005192","type":"SPLICE_VARIANT","name":null,"description":"In isoform 3 and isoform 5.","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":462}]},{"key":"other_topological_domain","label":"TOPOLOGICAL_DOMAIN","kind":"range","features":[{"begin":181,"end":184,"feature_id":null,"type":"TOPOLOGICAL_DOMAIN","name":null,"description":"Lumenal","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":404,"original_end":407},{"begin":206,"end":209,"feature_id":null,"type":"TOPOLOGICAL_DOMAIN","name":null,"description":"Cytoplasmic","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":429,"original_end":432},{"begin":231,"end":239,"feature_id":null,"type":"TOPOLOGICAL_DOMAIN","name":null,"description":"Lumenal","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":454,"original_end":462}]},{"key":"other_transmembrane_region","label":"TRANSMEMBRANE_REGION","kind":"range","features":[{"begin":185,"end":205,"feature_id":null,"type":"TRANSMEMBRANE_REGION","name":null,"description":"Helical","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":408,"original_end":428},{"begin":210,"end":230,"feature_id":null,"type":"TRANSMEMBRANE_REGION","name":null,"description":"Helical","value":null,"source":"UNIPROT","source_id":"P49768","provenance_source":null,"original_begin":433,"original_end":453}]}]},{"instance_id":"4UIS.A","entity_id":"1","label_asym_id":"A","auth_asym_id":"A","description":"GAMMA-SECRETASE","polymer_type":"polypeptide(L)","sequence":{"value":"IPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIAAVCDPLSDYNVWSMLKPIADDVVVAATRLDSRSFAWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVQKNESVRNQVEDLGAGVPAVILRSGVPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLAPEEDLNFVTDTAKALADVATVLGRALYELAGGDTVQADPQTVTRLLYGFLIKLRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTARLARALSPAQWSSTEYSTWTESRWKAIRARIFLIASXXXXXXXXXXXXXXXXXXXXXXX","length":588},"alignments":[{"source":"UNIPROT","target_id":"Q92542","target_sequence":"MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY","query_coverage":0.9608843537414966,"query_length":588,"target_coverage":0.7968970380818053,"target_length":709,"orientation":null,"regions":[{"query_begin":1,"query_end":565,"target_begin":42,"target_end":606,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":6,"end":7,"feature_id":"AA","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":6,"original_end":7},{"begin":12,"end":13,"feature_id":"AB","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":12,"original_end":13},{"begin":18,"end":19,"feature_id":"AB","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":18,"original_end":19},{"begin":28,"end":32,"feature_id":"AC","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":28,"original_end":32},{"begin":37,"end":46,"feature_id":"HELX_P1","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":37,"original_end":46},{"begin":53,"end":54,"feature_id":"AC","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":53,"original_end":54},{"begin":63,"end":72,"feature_id":"HELX_P2","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":63,"original_end":72},{"begin":80,"end":83,"feature_id":"AA","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":80,"original_end":83},{"begin":130,"end":133,"feature_id":"AA","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":130,"original_end":133},{"begin":135,"end":151,"feature_id":"HELX_P3","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":135,"original_end":151},{"begin":163,"end":168,"feature_id":"AC","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":163,"original_end":168},{"begin":176,"end":183,"feature_id":"HELX_P4","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":176,"original_end":183},{"begin":190,"end":192,"feature_id":"AD","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":190,"original_end":192},{"begin":195,"end":197,"feature_id":"AE","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":195,"original_end":197},{"begin":209,"end":211,"feature_id":"AF","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":209,"original_end":211},{"begin":214,"end":215,"feature_id":"AG","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":214,"original_end":215},{"begin":232,"end":248,"feature_id":"HELX_P5","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":232,"original_end":248},{"begin":249,"end":254,"feature_id":"HELX_P6","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":249,"original_end":254},{"begin":258,"end":260,"feature_id":"AF","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":258,"original_end":260},{"begin":263,"end":264,"feature_id":"AG","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":263,"original_end":264},{"begin":271,"end":283,"feature_id":"HELX_P7","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":271,"original_end":283},{"begin":299,"end":300,"feature_id":"AH","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":299,"original_end":300},{"begin":318,"end":334,"feature_id":"HELX_P8","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":318,"original_end":334},{"begin":349,"end":355,"feature_id":"HELX_P9","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":349,"original_end":355},{"begin":364,"end":365,"feature_id":"AH","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":364,"original_end":365},{"begin":382,"end":387,"feature_id":"HELX_P10","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":382,"original_end":387},{"begin":396,"end":401,"feature_id":"HELX_P11","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":396,"original_end":401},{"begin":406,"end":426,"feature_id":"HELX_P12","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":406,"original_end":426},{"begin":433,"end":446,"feature_id":"HELX_P13","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":433,"original_end":446},{"begin":448,"end":452,"feature_id":"HELX_P14","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":448,"original_end":452},{"begin":471,"end":485,"feature_id":"HELX_P15","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":471,"original_end":485},{"begin":496,"end":503,"feature_id":"HELX_P16","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":496,"original_end":503},{"begin":508,"end":509,"feature_id":"AI","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":508,"original_end":509},{"begin":522,"end":523,"feature_id":"AI","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":522,"original_end":523},{"begin":530,"end":532,"feature_id":"AE","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":530,"original_end":532},{"begin":549,"end":551,"feature_id":"AD","type":"SHEET","name":"sheet","description":"anti-parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":549,"original_end":551},{"begin":557,"end":562,"feature_id":"AC","type":"SHEET","name":"sheet","description":"mixed sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":557,"original_end":562},{"begin":565,"end":587,"feature_id":"HELX_P17","type":"HELIX_P","name":"helix","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PROMOTIF","original_begin":565,"original_end":587}]},{"key":"cis_peptide","label":"CIS-PEPTIDE","kind":"point","features":[{"begin":108,"end":109,"feature_id":"1","type":"CIS_PEPTIDE","name":"cis-peptide","description":"cis-peptide bond in model 1 with omega angle -10.37","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":108,"original_end":109},{"begin":154,"end":155,"feature_id":"2","type":"CIS_PEPTIDE","name":"cis-peptide","description":"cis-peptide bond in model 1 with omega angle 10.30","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":154,"original_end":155},{"begin":155,"end":156,"feature_id":"3","type":"CIS_PEPTIDE","name":"cis-peptide","description":"cis-peptide bond in model 1 with omega angle 3.37","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":155,"original_end":156},{"begin":157,"end":158,"feature_id":"4","type":"CIS_PEPTIDE","name":"cis-peptide","description":"cis-peptide bond in model 1 with omega angle -23.66","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":157,"original_end":158}]},{"key":"buried_residues","label":"BURIED RESIDUES","kind":"point","features":[{"begin":1,"end":588,"feature_id":null,"type":"BURIED_RESIDUES","name":"Unbound chain core residues","description":"Residue accessibility lower than 6Å","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"NBDB derivation matching RCSB Saguaro App","original_begin":1,"original_end":null,"values":[0,0,0,0,0,0,0,0,0,0,1.16,3.49,0,0,0,0,0,0,0,0,0,0,2.69,0,0,0,0,0,0,0.53,0,2.75,0,0,4.4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.8,5.37,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.26,2.95,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4.9,0,0,2.02,0,0,2.14,0,0,0,0,4.74,0,5.91,0,4.55,0,0,0,0,0,0,0,0,5.14,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.07,1.88,0,0,2.41,0,0,0,0,0,0,0,0,0,4.03,0,0,2.88,0,0,0,0,0,0,0,0,0,2.67,0,0,0,0,3.94,0,1.52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.51,4.29,0.25,0,3.76,0.23,0.23,0,4.55,0,3.76,0,0,0,0,1.77,4.13,0,0,2.81,0.8,1.61,3.22,0,4.17,2.68,2.92,0.23,0,1.8,0,0,0,2.59,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.26,2.0,1.27,3.3,2.32,4.24,0,0,0,1.45,0,0,0.26,4.19,0,3.49,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.97,3.11,0,4.81,0,0,0,0,0,0,0,2.54,3.92,0,0.8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.07,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4.29,2.88,0,1.61,0,0,0,0,0,0,0,0,0,0,0,0,0,1.59,2.92,0,0,0,0,0,0,0,0,0,0,4.81,0.25,0,0,0.98,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.61,0,0,3.49,4.53,0,4.83,0.26,0,5.14,0,2.07,0,0,5.67,0,0,0,5.6,0,0,0,0,0,0,0,0,0,0,0,1.34,2.23,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.08,0,4.03,0,0,0,0,0,0,0,0,0,0,0,5.1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.53,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.63,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":584,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.14,0.11,-0.21,-0.21,0.6,0.64,0.92,0.64,0.47,-0.2,-0.17,0.29,0.14,-0.67,-0.37,-0.66,-0.08,0.19,0.53,-0.36,-0.39,-0.71,0.14,0.73,0.47,0.43,0.99,0.64,0.6,0.29,-0.06,-0.91,-0.99,-1.02,-1.59,-1.59,-0.78,-0.42,-0.42,-0.08,0.13,-0.68,-0.47,-0.54,-1.16,-1.37,-0.82,-0.01,0.46,0.24,0.54,0.29,0.11,0.57,0.28,-0.69,-1.5,-1.5,-0.9,-1.2,-1.2,-0.42,-1.17,-1.13,-1.13,-0.82,-1.33,-2.04,-1.16,-0.52,-0.99,-0.13,0.11,1.08,1.07,1.58,2.0,1.07,0.69,0.64,0.04,0.04,-0.51,-0.47,-0.58,-0.59,-0.33,-0.24,0.31,0.1,0.18,0.09,-0.26,-0.96,-0.91,-0.42,-0.38,-0.38,-0.13,-0.77,-0.31,-0.42,-0.42,0.12,-0.58,-0.63,-1.49,-1.43,-0.66,-0.98,-0.87,-0.52,-0.6,-0.01,-0.06,-0.06,-0.36,-0.47,-0.51,0.19,0.06,0.13,0.24,0.81,1.62,1.62,0.92,0.62,-0.08,-0.29,-0.87,-1.61,-1.57,-1.49,-1.53,-1.53,-0.87,-0.62,-0.62,-0.93,-0.86,-1.71,-1.79,-1.44,-1.44,-2.11,-2.01,-1.71,-1.12,-0.94,-0.63,-0.74,-0.83,-0.02,0.64,0.89,1.19,0.6,1.2,1.59,1.19,1.01,0.8,0.17,0.17,0.42,1.31,0.8,0.41,0.7,0.98,1.04,1.61,0.91,-0.06,-0.64,-0.64,-0.07,-0.07,0.21,0.4,0.47,0.58,0.9,1.41,1.41,0.52,0.18,-0.41,-0.41,-0.79,-0.49,-0.1,-0.1,-0.44,-0.23,0.41,1.0,0.14,-0.14,0.41,0.67,0.71,1.34,1.72,1.14,0.44,1.26,1.26,0.7,-0.27,-0.82,-0.71,-0.71,-0.73,-0.62,-0.58,0.01,-0.08,0.38,0.67,-0.03,-0.32,-0.02,0.83,0.57,0.28,0.77,1.28,1.0,1.0,1.51,1.51,1.24,1.24,0.94,0.83,0.79,0.48,0.43,0.21,-0.17,-0.76,-0.49,-0.18,-0.46,-0.46,-0.24,-0.31,-0.9,-0.26,0.34,0.19,0.73,1.12,1.01,0.8,1.26,1.26,0.71,0.81,0.11,-0.5,-0.31,-0.67,-0.37,-0.41,-0.52,-0.23,-0.08,0.17,-0.08,-0.37,-0.71,-1.06,-1.01,-0.94,-0.84,-1.49,-0.88,-0.88,-0.67,-0.67,-0.62,-0.11,-0.07,-0.47,0.02,0.02,0.02,0.02,0.37,0.37,0.37,0.96,1.47,0.66,0.11,0.41,0.41,0.07,0.88,0.31,0.32,-0.46,-0.03,-0.34,-0.43,-0.39,-0.39,-1.24,-1.53,-2.13,-1.87,-1.32,-1.43,-1.64,-2.5,-1.64,-1.6,-1.6,-0.79,-0.74,-1.01,-0.56,0.3,0.51,0.24,1.1,1.99,1.99,1.53,1.24,1.24,1.24,1.24,1.47,0.82,0.14,-0.37,0.04,0.56,0.21,-0.76,-0.27,-0.27,-0.59,-0.21,-0.62,-0.92,-0.84,-0.54,-0.09,0.07,0.11,1.03,1.03,1.14,1.18,0.59,0.63,0.88,0.72,-0.1,-0.91,-1.54,-1.3,-1.09,-1.39,-1.43,-1.13,-1.59,-1.62,-1.31,-0.68,-0.92,-1.17,-0.28,-0.58,-0.61,-0.56,-0.31,-0.41,-1.0,-0.71,0.1,-0.2,0.01,-0.84,-1.14,-1.39,-0.79,-0.79,-0.38,-0.33,-0.61,-0.82,-0.51,0.08,0.03,-0.19,0.62,0.51,-0.34,0.2,0.79,0.79,1.06,1.91,1.67,0.74,0.74,1.56,0.94,0.36,0.86,0.59,0.12,0.12,0.23,-0.04,0.0,-0.24,0.34,-0.47,-0.84,-1.19,-1.22,-0.37,-0.37,-1.33,-0.52,-0.3,-0.06,0.08,0.78,1.28,1.31,0.96,1.88,0.96,0.14,-0.1,0.37,-0.44,-0.96,-1.6,-0.74,-1.21,-1.1,-0.76,-0.54,-0.54,-0.43,-0.7,-0.7,-0.62,-0.38,0.48,0.43,0.52,-0.08,0.23,0.2,0.27,-0.31,-0.66,-0.66,-0.1,-0.4,-0.37,-0.09,0.72,1.0,0.69,1.26,0.71,0.2,0.51,1.12,1.39,1.09,0.99,1.73,1.32,1.83,2.57,4.2,4.2,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,-0.7,0.55,-1.13,0.1,0.44,-0.38,-0.07,0.41,0.28,0.18,0.18,0.29,-0.23,-0.52,-0.11,-0.39,-1.2,-1.26,-1.17,-1.44,-1.16,-1.13,-1.43,-1.43,-1.86,-1.57,-1.86,-1.57,-0.99,-1.39,-1.11,-1.22,-0.63,0.18,0.7,1.63,1.63,1.04,1.74,1.73,2.77,2.42,2.33,1.83,0.5,-0.8,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":588,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.78,0.68,0.58,0.53,0.47,0.41,0.38,0.33,0.22,0.18,0.09,0.14,0.13,0.19,0.13,0.14,0.15,0.19,0.16,0.26,0.27,0.18,0.24,0.25,0.2,0.24,0.24,0.27,0.28,0.37,0.29,0.38,0.3,0.24,0.18,0.24,0.25,0.25,0.27,0.27,0.3,0.39,0.39,0.38,0.38,0.37,0.28,0.29,0.27,0.26,0.24,0.23,0.23,0.31,0.37,0.37,0.35,0.35,0.34,0.25,0.25,0.23,0.21,0.28,0.3,0.37,0.38,0.42,0.41,0.35,0.34,0.28,0.36,0.3,0.3,0.29,0.38,0.41,0.42,0.39,0.45,0.45,0.37,0.36,0.38,0.38,0.31,0.39,0.34,0.36,0.41,0.46,0.51,0.42,0.49,0.42,0.34,0.3,0.21,0.18,0.23,0.17,0.19,0.18,0.18,0.16,0.1,0.14,0.13,0.19,0.11,0.09,0.05,0.06,0.11,0.06,0.09,0.09,0.12,0.13,0.08,0.05,0.05,0.04,0.08,0.09,0.09,0.16,0.16,0.15,0.11,0.11,0.12,0.19,0.11,0.06,0.11,0.12,0.18,0.15,0.14,0.2,0.28,0.35,0.34,0.32,0.27,0.3,0.28,0.2,0.23,0.23,0.19,0.17,0.13,0.22,0.23,0.15,0.14,0.13,0.11,0.17,0.14,0.1,0.06,0.06,0.06,0.06,0.05,0.03,0.03,0.03,0.04,0.09,0.11,0.08,0.06,0.07,0.09,0.05,0.06,0.08,0.05,0.06,0.09,0.08,0.08,0.05,0.04,0.04,0.07,0.05,0.05,0.06,0.04,0.03,0.05,0.07,0.06,0.06,0.07,0.05,0.04,0.06,0.06,0.03,0.07,0.06,0.09,0.13,0.08,0.08,0.08,0.09,0.05,0.06,0.1,0.09,0.07,0.12,0.16,0.18,0.16,0.17,0.17,0.11,0.12,0.12,0.13,0.08,0.07,0.11,0.11,0.17,0.13,0.12,0.16,0.12,0.1,0.14,0.13,0.09,0.11,0.15,0.11,0.13,0.2,0.27,0.2,0.16,0.15,0.13,0.1,0.07,0.07,0.08,0.15,0.14,0.09,0.12,0.06,0.04,0.06,0.06,0.06,0.1,0.06,0.04,0.02,0.04,0.04,0.07,0.1,0.16,0.23,0.13,0.16,0.1,0.1,0.11,0.12,0.17,0.18,0.18,0.19,0.12,0.1,0.13,0.13,0.21,0.2,0.19,0.16,0.12,0.11,0.12,0.2,0.12,0.19,0.13,0.13,0.1,0.1,0.15,0.15,0.17,0.19,0.26,0.24,0.31,0.32,0.31,0.32,0.34,0.41,0.43,0.37,0.38,0.46,0.38,0.46,0.51,0.54,0.48,0.5,0.47,0.38,0.38,0.3,0.31,0.31,0.3,0.23,0.31,0.24,0.27,0.28,0.35,0.34,0.24,0.33,0.32,0.26,0.17,0.23,0.17,0.2,0.26,0.23,0.31,0.3,0.23,0.17,0.16,0.12,0.18,0.17,0.14,0.13,0.11,0.11,0.1,0.1,0.16,0.16,0.1,0.14,0.13,0.08,0.09,0.1,0.1,0.12,0.18,0.25,0.2,0.19,0.13,0.14,0.09,0.13,0.22,0.15,0.1,0.08,0.15,0.23,0.23,0.24,0.24,0.31,0.22,0.17,0.19,0.19,0.18,0.23,0.21,0.25,0.18,0.22,0.21,0.14,0.18,0.25,0.23,0.13,0.12,0.11,0.08,0.08,0.05,0.1,0.08,0.06,0.06,0.06,0.07,0.08,0.06,0.1,0.09,0.08,0.15,0.17,0.17,0.17,0.23,0.23,0.16,0.12,0.12,0.18,0.1,0.11,0.08,0.08,0.05,0.05,0.05,0.09,0.05,0.07,0.07,0.03,0.02,0.02,0.03,0.03,0.04,0.04,0.07,0.1,0.06,0.06,0.08,0.09,0.09,0.13,0.15,0.14,0.13,0.2,0.19,0.14,0.16,0.19,0.19,0.13,0.12,0.07,0.1,0.1,0.07,0.12,0.19,0.22,0.25,0.21,0.2,0.17,0.16,0.15,0.15,0.15,0.18,0.22,0.26,0.24,0.29,0.31,0.35,0.37,0.36,0.4,0.4,0.4,0.4,0.43,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.46,0.47,0.47,0.47,0.44,0.43,0.43,0.43,0.4,0.4,0.42,0.41,0.42,0.37,0.38,0.38,0.38,0.39,0.33,0.33,0.34,0.29,0.29,0.3,0.3,0.33,0.29,0.29,0.29,0.28,0.27,0.24,0.25,0.2,0.23,0.2,0.17,0.16,0.15,0.21,0.2,0.2,0.25,0.24,0.23,0.23,0.23,0.27,0.27,0.27,0.32,0.32,0.33,0.33,0.37,0.39,0.42,0.45,0.46,0.46,0.46,0.46,0.51,0.56,0.61,0.66,0.71,0.75,0.8,0.85,0.89,0.92]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":588,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.32,0.33,0.33,0.34,0.34,0.35,0.36,0.37,0.37,0.38,0.39,0.39,0.39,0.38,0.38,0.37,0.36,0.35,0.34,0.34,0.33,0.33,0.33,0.34,0.36,0.37,0.38,0.4,0.41,0.42,0.43,0.43,0.42,0.41,0.41,0.41,0.41,0.41,0.41,0.41,0.41,0.41,0.41,0.4,0.4,0.4,0.39,0.38,0.37,0.36,0.36,0.34,0.33,0.33,0.32,0.32,0.32,0.33,0.33,0.34,0.34,0.34,0.36,0.37,0.38,0.39,0.4,0.41,0.41,0.41,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.41,0.42,0.43,0.43,0.42,0.4,0.38,0.37,0.35,0.33,0.31,0.3,0.29,0.28,0.28,0.28,0.28,0.29,0.29,0.29,0.29,0.29,0.3,0.3,0.32,0.32,0.32,0.32,0.31,0.3,0.31,0.33,0.34,0.35,0.36,0.35,0.37,0.39,0.4,0.42,0.42,0.39,0.37,0.35,0.33,0.31,0.29,0.28,0.28,0.28,0.28,0.29,0.31,0.34,0.37,0.42,0.38,0.33,0.29,0.25,0.21,0.18,0.16,0.13,0.12,0.1,0.1,0.1,0.11,0.11,0.11,0.11,0.12,0.12,0.12,0.12,0.13,0.13,0.14,0.14,0.15,0.15,0.16,0.16,0.19,0.22,0.24,0.26,0.28,0.28,0.28,0.28,0.28,0.27,0.26,0.24,0.2,0.18,0.16,0.14,0.13,0.13,0.13,0.13,0.13,0.13,0.13,0.13,0.13,0.13,0.13,0.14,0.14,0.14,0.14,0.14,0.14,0.14,0.16,0.17,0.18,0.19,0.19,0.19,0.2,0.21,0.22,0.24,0.24,0.24,0.24,0.25,0.25,0.25,0.26,0.27,0.28,0.28,0.27,0.27,0.28,0.28,0.28,0.28,0.27,0.25,0.24,0.23,0.22,0.21,0.2,0.19,0.18,0.17,0.16,0.16,0.16,0.16,0.16,0.16,0.16,0.16,0.17,0.17,0.18,0.18,0.19,0.2,0.2,0.2,0.21,0.22,0.22,0.23,0.24,0.24,0.24,0.24,0.24,0.25,0.26,0.26,0.26,0.26,0.26,0.25,0.24,0.24,0.24,0.23,0.23,0.21,0.21,0.21,0.22,0.22,0.22,0.23,0.24,0.25,0.26,0.27,0.28,0.29,0.29,0.3,0.31,0.32,0.32,0.32,0.32,0.32,0.31,0.32,0.32,0.32,0.32,0.32,0.32,0.32,0.33,0.34,0.36,0.38,0.41,0.43,0.42,0.39,0.37,0.36,0.35,0.34,0.34,0.35,0.37,0.39,0.42,0.42,0.39,0.36,0.34,0.33,0.32,0.31,0.31,0.31,0.32,0.33,0.34,0.35,0.36,0.37,0.38,0.38,0.38,0.39,0.39,0.39,0.39,0.39,0.39,0.39,0.39,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.42,0.4,0.39,0.38,0.37,0.37,0.37,0.36,0.37,0.37,0.38,0.38,0.39,0.39,0.38,0.38,0.37,0.37,0.37,0.35,0.35,0.34,0.33,0.32,0.31,0.31,0.31,0.3,0.3,0.3,0.31,0.32,0.33,0.35,0.37,0.4,0.43,0.42,0.4,0.38,0.37,0.37,0.37,0.37,0.39,0.41,0.43,0.4,0.38,0.36,0.34,0.32,0.3,0.29,0.28,0.27,0.26,0.26,0.26,0.26,0.27,0.27,0.28,0.28,0.29,0.3,0.31,0.32,0.32,0.32,0.32,0.32,0.32,0.31,0.31,0.31,0.3,0.3,0.29,0.29,0.29,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.3,0.31,0.32,0.32,0.33,0.34,0.34,0.36,0.38,0.39,0.4,0.41,0.41,0.42,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.41,0.4,0.38,0.37,0.36,0.37,0.37,0.37,0.38,0.38,0.4,0.41,0.42,0.43,0.43,0.43,0.44,0.43,0.43,0.42,0.41,0.4,0.4,0.39,0.38,0.37,0.37,0.36,0.35,0.35,0.34,0.34,0.33,0.33,0.32,0.32,0.32,0.32,0.32,0.32,0.32,0.31,0.31,0.31,0.3,0.3,0.44,0.3,0.3,0.31,0.32,0.34,0.35,0.37,0.39,0.4,0.42,0.43,0.45,0.46,0.46,0.46,0.46,0.45,0.45,0.45,0.44,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.45,0.46,0.46,0.47,0.47,0.47,0.47,0.47,0.47,0.46,0.45,0.45,0.44,0.43,0.43,0.42,0.41,0.4,0.39,0.39,0.44,0.38,0.38,0.38,0.37,0.37,0.36,0.36,0.35,0.34,0.33,0.32,0.31,0.3]}]},{"key":"pfam","label":"PFAM","kind":"range","features":[{"begin":8,"end":173,"feature_id":"PF18266","type":"PFAM","name":"Nicastrin small lobe (Ncstrn_small)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"Pfam","original_begin":8,"original_end":173},{"begin":209,"end":422,"feature_id":"PF05450","type":"PFAM","name":"Nicastrin large lobe (Nicastrin)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"Pfam","original_begin":209,"original_end":422}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":1,"end":200,"feature_id":"e4uisA2","type":"ECOD","name":"PCI","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"ECOD","original_begin":1,"original_end":200},{"begin":193,"end":489,"feature_id":"e4uisA1","type":"ECOD","name":"PCI","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"ECOD","original_begin":193,"original_end":489}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":565,"feature_id":"PRO_0000019681","type":"CHAIN","name":null,"description":"Nicastrin","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":42,"original_end":606}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":295,"end":296,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases production of amyloid-beta (beta-APP40 and beta-APP42) in APP processing.","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":336,"original_end":337}]},{"key":"site","label":"SITE","kind":"point","features":[{"begin":4,"end":4,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":45,"original_end":45},{"begin":14,"end":14,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":55,"original_end":55},{"begin":146,"end":146,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":187,"original_end":187},{"begin":159,"end":159,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":200,"original_end":200},{"begin":163,"end":163,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":204,"original_end":204},{"begin":223,"end":223,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":264,"original_end":264},{"begin":346,"end":346,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":387,"original_end":387},{"begin":376,"end":376,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":417,"original_end":417},{"begin":394,"end":394,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":435,"original_end":435},{"begin":423,"end":423,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":464,"original_end":464},{"begin":465,"end":465,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":506,"original_end":506},{"begin":489,"end":489,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":530,"original_end":530},{"begin":521,"end":521,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":562,"original_end":562},{"begin":532,"end":532,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":573,"original_end":573},{"begin":539,"end":539,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (GlcNAc...) asparagine","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":580,"original_end":580}]},{"key":"other_disulfide_bridge","label":"DISULFIDE_BRIDGE","kind":"range","features":[{"begin":9,"end":21,"feature_id":null,"type":"DISULFIDE_BRIDGE","name":"disulfide bridge","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":9,"original_end":21},{"begin":145,"end":163,"feature_id":null,"type":"DISULFIDE_BRIDGE","name":"disulfide bridge","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":145,"original_end":163},{"begin":180,"end":190,"feature_id":null,"type":"DISULFIDE_BRIDGE","name":"disulfide bridge","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":180,"original_end":190}]},{"key":"other_membrane_segment","label":"MEMBRANE_SEGMENT","kind":"range","features":[{"begin":565,"end":585,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"OPM","original_begin":565,"original_end":585},{"begin":574,"end":586,"feature_id":null,"type":"MEMBRANE_SEGMENT","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDBTM","original_begin":574,"original_end":586}]},{"key":"other_modified_monomer","label":"MODIFIED_MONOMER","kind":"point","features":[{"begin":490,"end":490,"feature_id":"monomer_feature_1","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":490,"original_end":490},{"begin":491,"end":491,"feature_id":"monomer_feature_2","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":491,"original_end":491},{"begin":492,"end":492,"feature_id":"monomer_feature_3","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":492,"original_end":492},{"begin":493,"end":493,"feature_id":"monomer_feature_4","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":493,"original_end":493},{"begin":494,"end":494,"feature_id":"monomer_feature_5","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":494,"original_end":494},{"begin":495,"end":495,"feature_id":"monomer_feature_6","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":495,"original_end":495},{"begin":496,"end":496,"feature_id":"monomer_feature_7","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":496,"original_end":496},{"begin":497,"end":497,"feature_id":"monomer_feature_8","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":497,"original_end":497},{"begin":498,"end":498,"feature_id":"monomer_feature_9","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":498,"original_end":498},{"begin":499,"end":499,"feature_id":"monomer_feature_10","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":499,"original_end":499},{"begin":500,"end":500,"feature_id":"monomer_feature_11","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":500,"original_end":500},{"begin":501,"end":501,"feature_id":"monomer_feature_12","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":501,"original_end":501},{"begin":502,"end":502,"feature_id":"monomer_feature_13","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":502,"original_end":502},{"begin":503,"end":503,"feature_id":"monomer_feature_14","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":503,"original_end":503},{"begin":504,"end":504,"feature_id":"monomer_feature_15","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":504,"original_end":504},{"begin":505,"end":505,"feature_id":"monomer_feature_16","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":505,"original_end":505},{"begin":506,"end":506,"feature_id":"monomer_feature_17","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":506,"original_end":506},{"begin":507,"end":507,"feature_id":"monomer_feature_18","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":507,"original_end":507},{"begin":508,"end":508,"feature_id":"monomer_feature_19","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":508,"original_end":508},{"begin":509,"end":509,"feature_id":"monomer_feature_20","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":509,"original_end":509},{"begin":510,"end":510,"feature_id":"monomer_feature_21","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":510,"original_end":510},{"begin":511,"end":511,"feature_id":"monomer_feature_22","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":511,"original_end":511},{"begin":512,"end":512,"feature_id":"monomer_feature_23","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":512,"original_end":512},{"begin":513,"end":513,"feature_id":"monomer_feature_24","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":513,"original_end":513},{"begin":514,"end":514,"feature_id":"monomer_feature_25","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":514,"original_end":514},{"begin":515,"end":515,"feature_id":"monomer_feature_26","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":515,"original_end":515},{"begin":516,"end":516,"feature_id":"monomer_feature_27","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":516,"original_end":516},{"begin":517,"end":517,"feature_id":"monomer_feature_28","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":517,"original_end":517},{"begin":518,"end":518,"feature_id":"monomer_feature_29","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":518,"original_end":518},{"begin":519,"end":519,"feature_id":"monomer_feature_30","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":519,"original_end":519},{"begin":520,"end":520,"feature_id":"monomer_feature_31","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":520,"original_end":520},{"begin":521,"end":521,"feature_id":"monomer_feature_32","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":521,"original_end":521},{"begin":522,"end":522,"feature_id":"monomer_feature_33","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":522,"original_end":522},{"begin":523,"end":523,"feature_id":"monomer_feature_34","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":523,"original_end":523},{"begin":524,"end":524,"feature_id":"monomer_feature_35","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":524,"original_end":524},{"begin":525,"end":525,"feature_id":"monomer_feature_36","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":525,"original_end":525},{"begin":526,"end":526,"feature_id":"monomer_feature_37","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":526,"original_end":526},{"begin":527,"end":527,"feature_id":"monomer_feature_38","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":527,"original_end":527},{"begin":566,"end":566,"feature_id":"monomer_feature_39","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":566,"original_end":566},{"begin":567,"end":567,"feature_id":"monomer_feature_40","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":567,"original_end":567},{"begin":568,"end":568,"feature_id":"monomer_feature_41","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":568,"original_end":568},{"begin":569,"end":569,"feature_id":"monomer_feature_42","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":569,"original_end":569},{"begin":570,"end":570,"feature_id":"monomer_feature_43","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":570,"original_end":570},{"begin":571,"end":571,"feature_id":"monomer_feature_44","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":571,"original_end":571},{"begin":572,"end":572,"feature_id":"monomer_feature_45","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":572,"original_end":572},{"begin":573,"end":573,"feature_id":"monomer_feature_46","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":573,"original_end":573},{"begin":574,"end":574,"feature_id":"monomer_feature_47","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":574,"original_end":574},{"begin":575,"end":575,"feature_id":"monomer_feature_48","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":575,"original_end":575},{"begin":576,"end":576,"feature_id":"monomer_feature_49","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":576,"original_end":576},{"begin":577,"end":577,"feature_id":"monomer_feature_50","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":577,"original_end":577},{"begin":578,"end":578,"feature_id":"monomer_feature_51","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":578,"original_end":578},{"begin":579,"end":579,"feature_id":"monomer_feature_52","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":579,"original_end":579},{"begin":580,"end":580,"feature_id":"monomer_feature_53","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":580,"original_end":580},{"begin":581,"end":581,"feature_id":"monomer_feature_54","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":581,"original_end":581},{"begin":582,"end":582,"feature_id":"monomer_feature_55","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":582,"original_end":582},{"begin":583,"end":583,"feature_id":"monomer_feature_56","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":583,"original_end":583},{"begin":584,"end":584,"feature_id":"monomer_feature_57","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":584,"original_end":584},{"begin":585,"end":585,"feature_id":"monomer_feature_58","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":585,"original_end":585},{"begin":586,"end":586,"feature_id":"monomer_feature_59","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":586,"original_end":586},{"begin":587,"end":587,"feature_id":"monomer_feature_60","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":587,"original_end":587},{"begin":588,"end":588,"feature_id":"monomer_feature_61","type":"MODIFIED_MONOMER","name":null,"description":null,"value":null,"source":"PDB_ENTITY","source_id":"4UIS_1","provenance_source":"PDB","original_begin":588,"original_end":588}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":34,"end":34,"feature_id":"VAR_050274","type":"SEQUENCE_VARIANT","name":null,"description":"In dbSNP:rs12045198.","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":75,"original_end":75},{"begin":36,"end":36,"feature_id":"VAR_050275","type":"SEQUENCE_VARIANT","name":null,"description":"In dbSNP:rs35603924.","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":77,"original_end":77},{"begin":170,"end":170,"feature_id":"VAR_067756","type":"SEQUENCE_VARIANT","name":null,"description":"In ACNINV1.","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":211,"original_end":211}]},{"key":"other_topological_domain","label":"TOPOLOGICAL_DOMAIN","kind":"range","features":[{"begin":1,"end":565,"feature_id":null,"type":"TOPOLOGICAL_DOMAIN","name":null,"description":"Extracellular","value":null,"source":"UNIPROT","source_id":"Q92542","provenance_source":null,"original_begin":42,"original_end":606}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"range","features":[{"begin":285,"end":286,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":285,"original_end":286},{"begin":306,"end":309,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":306,"original_end":309},{"begin":447,"end":447,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"4UIS.A","provenance_source":"PDB","original_begin":447,"original_end":447}]}]}],"errors":[]}