{"schema_version":"1.0","pdb_id":"6GX5","generated_at":"2026-09-06T17:59:59Z","status":"complete","coordinate_system":{"reference":"PDB_INSTANCE","index_base":1,"end_inclusive":true},"sources":{"sequence_coordinates_api":"https://sequence-coordinates.rcsb.org/graphql","annotation_collections":["UNIPROT","PDB_ENTITY","PDB_INSTANCE","PDB_INTERFACE"]},"chains":[{"instance_id":"6GX5.C","entity_id":"1","label_asym_id":"C","auth_asym_id":"C","description":"Microtubule-associated protein tau","polymer_type":"polypeptide(L)","sequence":{"value":"KNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF","length":94},"alignments":[{"source":"UNIPROT","target_id":"P10636","target_sequence":"MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL","query_coverage":1.0,"query_length":94,"target_coverage":0.12401055408970976,"target_length":758,"orientation":null,"regions":[{"query_begin":1,"query_end":94,"target_begin":602,"target_end":695,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":2,"end":7,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":2,"original_end":7},{"begin":10,"end":15,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":10,"original_end":15},{"begin":21,"end":26,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":21,"original_end":26},{"begin":29,"end":30,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":29,"original_end":30},{"begin":34,"end":37,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":34,"original_end":37},{"begin":40,"end":41,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":40,"original_end":41},{"begin":44,"end":46,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":44,"original_end":46},{"begin":52,"end":70,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":52,"original_end":70},{"begin":75,"end":78,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":75,"original_end":78},{"begin":85,"end":93,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PROMOTIF","original_begin":85,"original_end":93}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":1,"end":1,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[1.0]},{"begin":14,"end":14,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":14,"original_end":null,"values":[1.0]},{"begin":17,"end":17,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":17,"original_end":null,"values":[2.0]},{"begin":25,"end":25,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":25,"original_end":null,"values":[1.0]},{"begin":27,"end":27,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":27,"original_end":null,"values":[1.0]},{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":56,"end":56,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":56,"original_end":null,"values":[2.0]},{"begin":71,"end":71,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":71,"original_end":null,"values":[1.0]},{"begin":74,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":74,"original_end":null,"values":[1.0]},{"begin":78,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":78,"original_end":null,"values":[2.0]},{"begin":91,"end":91,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":91,"original_end":null,"values":[1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[0.411,0.539,0.609,0.382,0.594,0.546,0.575,0.534,0.573,0.588,0.422,0.554,0.58,0.433,0.548,0.543,0.519,0.559,0.574,0.543,0.612,0.582,0.604,0.603,0.569,0.568,0.33,0.52,0.504,0.522,0.537,0.518,0.375,0.567,0.538,0.583,0.395,0.479,0.618,0.491,0.509,0.573,0.542,0.563,0.596,0.561,0.506,0.513,0.565,0.543,0.546,0.551,0.568,0.321,0.575,0.348,0.639,0.457,0.536,0.576,0.475,0.528,0.536,0.493,0.571,0.549,0.538,0.608,0.392,0.574,0.541,0.53,0.583,0.399,0.505,0.523,0.521,0.623,0.508,0.624,0.45,0.555,0.56,0.485,0.44,0.341,0.501,0.387,0.571,0.629,0.561,0.533,0.498,0.601]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":90,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[-0.94,-0.59,-0.59,-1.44,-0.59,-0.93,-0.86,-1.74,-1.88,-1.83,-1.8,-1.46,-1.5,-1.46,-1.41,-0.56,0.3,0.33,-0.06,-0.19,0.32,0.37,0.32,0.62,-0.31,-0.31,-0.24,0.1,-0.16,-0.34,0.0,-0.51,0.0,0.39,-0.47,0.11,-0.16,-0.08,-0.79,-0.92,-0.88,-1.34,-1.34,-1.34,-1.38,-1.41,-0.59,-0.59,-0.5,-0.84,-1.23,-0.77,-0.77,-0.92,-0.97,-1.82,-1.89,-1.33,-1.33,-0.99,-1.84,-0.96,-1.31,-0.97,-0.16,-0.04,-0.9,-0.01,0.0,0.08,0.04,-0.09,-0.04,-0.51,-0.17,-0.17,-1.1,-1.46,-0.6,-1.46,-1.36,-1.67,-2.06,-1.59,-1.28,-0.53]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.94,0.92,0.86,0.82,0.8,0.76,0.75,0.71,0.67,0.63,0.59,0.55,0.55,0.55,0.51,0.44,0.44,0.53,0.49,0.5,0.45,0.46,0.45,0.47,0.46,0.45,0.45,0.35,0.36,0.37,0.31,0.31,0.36,0.28,0.35,0.4,0.46,0.48,0.46,0.5,0.5,0.56,0.51,0.51,0.51,0.52,0.51,0.52,0.59,0.54,0.53,0.53,0.53,0.53,0.59,0.54,0.55,0.55,0.53,0.47,0.48,0.48,0.41,0.46,0.46,0.44,0.43,0.44,0.38,0.41,0.47,0.47,0.55,0.55,0.53,0.53,0.5,0.48,0.47,0.48,0.53,0.47,0.46,0.44,0.48,0.52,0.62,0.67,0.69,0.77,0.78,0.82,0.85,0.87]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.44,0.44,0.46,0.47,0.49,0.51,0.53,0.54,0.56,0.56,0.56,0.56,0.56,0.54,0.54,0.52,0.5,0.49,0.48,0.48,0.48,0.48,0.48,0.48,0.49,0.48,0.48,0.49,0.48,0.48,0.47,0.46,0.45,0.44,0.44,0.43,0.44,0.43,0.43,0.43,0.44,0.44,0.45,0.47,0.47,0.48,0.48,0.48,0.49,0.49,0.49,0.49,0.49,0.5,0.5,0.5,0.5,0.49,0.49,0.49,0.49,0.49,0.48,0.47,0.45,0.45,0.44,0.44,0.44,0.44,0.45,0.45,0.45,0.46,0.46,0.47,0.48,0.49]}]},{"key":"pfam","label":"PFAM","kind":"range","features":[{"begin":1,"end":21,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":1,"original_end":21},{"begin":22,"end":52,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":22,"original_end":52},{"begin":53,"end":84,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":53,"original_end":84}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":94,"feature_id":"PRO_0000072739","type":"CHAIN","name":null,"description":"Microtubule-associated protein tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":695},{"begin":14,"end":14,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":91,"end":91,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":17,"end":17,"feature_id":"VAR_010348","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; most common mutation; reduction in the ability to promote microtubule assembly; accelerates aggregation of tau into filaments; dbSNP:rs63751273.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618}]},{"key":"site","label":"SITE","kind":"point","features":[{"begin":6,"end":6,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":10,"end":10,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":611,"original_end":611},{"begin":14,"end":14,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":56,"end":56,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":657,"original_end":657},{"begin":59,"end":59,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":86,"end":86,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":687,"original_end":687},{"begin":91,"end":91,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"other_bond_outliers","label":"BOND_OUTLIERS","kind":"numeric_series","features":[{"begin":16,"end":16,"feature_id":"BOND_OUTLIERS","type":"BOND_OUTLIERS","name":"BOND_OUTLIERS","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.C","provenance_source":"PDB","original_begin":16,"original_end":null,"values":[1.0]}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":602},{"begin":6,"end":6,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":9,"end":9,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":610,"original_end":610},{"begin":14,"end":14,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":21,"end":21,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6,N6-dimethyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":40,"end":40,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":641,"original_end":641},{"begin":47,"end":47,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":65,"end":65,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Omega-N-methylarginine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":666,"original_end":666},{"begin":68,"end":68,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":72,"end":72,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":673,"original_end":673},{"begin":85,"end":85,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":1,"end":84,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Microtubule-binding domain","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":685}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":1,"end":21,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 2","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622},{"begin":22,"end":52,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 3","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":623,"original_end":653},{"begin":53,"end":84,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 4","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":685}]},{"key":"other_sequence_conflict","label":"SEQUENCE_CONFLICT","kind":"point","features":[{"begin":16,"end":16,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":21,"end":21,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":12,"end":12,"feature_id":"VAR_019663","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level; dbSNP:rs63750416.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":12,"end":12,"feature_id":"VAR_019664","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1/atypical PSNP1; heterozygosity may be a risk factor for both a PSNP1-like syndrome and Parkinson disease; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":16,"end":16,"feature_id":"VAR_064624","type":"SEQUENCE_VARIANT","name":null,"description":"In dbSNP:rs116733906.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":17,"end":17,"feature_id":"VAR_010349","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1 and CBD; reduction in the ability to promote microtubule assembly; dbSNP:rs63751438.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618},{"begin":19,"end":19,"feature_id":"VAR_037439","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1; dbSNP:rs63751391.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":620,"original_end":620},{"begin":21,"end":21,"feature_id":"VAR_010350","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; minimal parkinsonism; very early age of onset; dbSNP:rs63751165.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":33,"end":33,"feature_id":"VAR_037440","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750092.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":36,"end":36,"feature_id":"VAR_019665","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; markedly reduced ability of tau to promote microtubule assembly; dbSNP:rs63750635.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":637,"original_end":637},{"begin":53,"end":53,"feature_id":"VAR_010351","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; ultrastructural and biochemical characteristics indistinguishable from Alzheimer disease; accelerates aggregation of tau into filaments; dbSNP:rs63750570.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":654},{"begin":58,"end":58,"feature_id":"VAR_019666","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750711.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":659,"original_end":659},{"begin":68,"end":68,"feature_id":"VAR_019667","type":"SEQUENCE_VARIANT","name":null,"description":"In fatal respiratory hypoventilation; unusual apparent autosomal recessive inheritance; reduced binding to microtubules as well as increased fibrillization and aggregation; dbSNP:rs63750425.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":85,"end":85,"feature_id":"VAR_019668","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; 90% reduction in the rate of microtubule assembly; dbSNP:rs63751264.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":1,"end":21,"feature_id":"VSP_003181","type":"SPLICE_VARIANT","name":null,"description":"In isoform Tau-A, isoform Tau-B, isoform Tau-C and isoform Fetal-tau.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622}]}]},{"instance_id":"6GX5.B","entity_id":"1","label_asym_id":"B","auth_asym_id":"B","description":"Microtubule-associated protein tau","polymer_type":"polypeptide(L)","sequence":{"value":"KNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF","length":94},"alignments":[{"source":"UNIPROT","target_id":"P10636","target_sequence":"MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL","query_coverage":1.0,"query_length":94,"target_coverage":0.12401055408970976,"target_length":758,"orientation":null,"regions":[{"query_begin":1,"query_end":94,"target_begin":602,"target_end":695,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":2,"end":7,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":2,"original_end":7},{"begin":10,"end":15,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":10,"original_end":15},{"begin":21,"end":26,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":21,"original_end":26},{"begin":29,"end":30,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":29,"original_end":30},{"begin":34,"end":37,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":34,"original_end":37},{"begin":40,"end":41,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":40,"original_end":41},{"begin":44,"end":46,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":44,"original_end":46},{"begin":52,"end":70,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":52,"original_end":70},{"begin":75,"end":78,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":75,"original_end":78},{"begin":85,"end":93,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PROMOTIF","original_begin":85,"original_end":93}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":1,"end":1,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[1.0]},{"begin":14,"end":14,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":14,"original_end":null,"values":[1.0]},{"begin":17,"end":17,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":17,"original_end":null,"values":[2.0]},{"begin":25,"end":25,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":25,"original_end":null,"values":[1.0]},{"begin":27,"end":27,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":27,"original_end":null,"values":[1.0]},{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":56,"end":56,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":56,"original_end":null,"values":[2.0]},{"begin":71,"end":71,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":71,"original_end":null,"values":[1.0]},{"begin":74,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":74,"original_end":null,"values":[1.0]},{"begin":78,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":78,"original_end":null,"values":[2.0]},{"begin":91,"end":91,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":91,"original_end":null,"values":[1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[0.393,0.534,0.586,0.45,0.609,0.577,0.581,0.55,0.526,0.59,0.455,0.606,0.551,0.419,0.616,0.563,0.542,0.593,0.576,0.606,0.577,0.549,0.598,0.602,0.565,0.552,0.352,0.582,0.571,0.537,0.551,0.469,0.368,0.538,0.574,0.502,0.388,0.583,0.627,0.475,0.527,0.605,0.569,0.559,0.614,0.575,0.566,0.497,0.538,0.546,0.594,0.554,0.547,0.424,0.559,0.382,0.571,0.414,0.603,0.573,0.506,0.511,0.539,0.488,0.559,0.564,0.548,0.596,0.404,0.634,0.57,0.517,0.556,0.382,0.556,0.57,0.553,0.582,0.545,0.583,0.51,0.554,0.52,0.515,0.521,0.387,0.467,0.277,0.587,0.582,0.566,0.566,0.491,0.616]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":90,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[-0.94,-0.59,-0.59,-1.44,-0.59,-0.93,-0.86,-1.74,-1.88,-1.83,-1.8,-1.46,-1.5,-1.46,-1.41,-0.56,0.3,0.33,-0.06,-0.19,0.32,0.37,0.32,0.62,-0.31,-0.31,-0.24,0.1,-0.16,-0.34,0.0,-0.51,0.0,0.39,-0.47,0.11,-0.16,-0.08,-0.79,-0.92,-0.88,-1.34,-1.34,-1.34,-1.38,-1.41,-0.59,-0.59,-0.5,-0.84,-1.23,-0.77,-0.77,-0.92,-0.97,-1.82,-1.89,-1.33,-1.33,-0.99,-1.84,-0.96,-1.31,-0.97,-0.16,-0.04,-0.9,-0.01,0.0,0.08,0.04,-0.09,-0.04,-0.51,-0.17,-0.17,-1.1,-1.46,-0.6,-1.46,-1.36,-1.67,-2.06,-1.59,-1.28,-0.53]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.94,0.92,0.86,0.82,0.8,0.76,0.75,0.71,0.67,0.63,0.59,0.55,0.55,0.55,0.51,0.44,0.44,0.53,0.49,0.5,0.45,0.46,0.45,0.47,0.46,0.45,0.45,0.35,0.36,0.37,0.31,0.31,0.36,0.28,0.35,0.4,0.46,0.48,0.46,0.5,0.5,0.56,0.51,0.51,0.51,0.52,0.51,0.52,0.59,0.54,0.53,0.53,0.53,0.53,0.59,0.54,0.55,0.55,0.53,0.47,0.48,0.48,0.41,0.46,0.46,0.44,0.43,0.44,0.38,0.41,0.47,0.47,0.55,0.55,0.53,0.53,0.5,0.48,0.47,0.48,0.53,0.47,0.46,0.44,0.48,0.52,0.62,0.67,0.69,0.77,0.78,0.82,0.85,0.87]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.44,0.44,0.46,0.47,0.49,0.51,0.53,0.54,0.56,0.56,0.56,0.56,0.56,0.54,0.54,0.52,0.5,0.49,0.48,0.48,0.48,0.48,0.48,0.48,0.49,0.48,0.48,0.49,0.48,0.48,0.47,0.46,0.45,0.44,0.44,0.43,0.44,0.43,0.43,0.43,0.44,0.44,0.45,0.47,0.47,0.48,0.48,0.48,0.49,0.49,0.49,0.49,0.49,0.5,0.5,0.5,0.5,0.49,0.49,0.49,0.49,0.49,0.48,0.47,0.45,0.45,0.44,0.44,0.44,0.44,0.45,0.45,0.45,0.46,0.46,0.47,0.48,0.49]}]},{"key":"pfam","label":"PFAM","kind":"range","features":[{"begin":1,"end":21,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":1,"original_end":21},{"begin":22,"end":52,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":22,"original_end":52},{"begin":53,"end":84,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":53,"original_end":84}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":94,"feature_id":"PRO_0000072739","type":"CHAIN","name":null,"description":"Microtubule-associated protein tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":695},{"begin":14,"end":14,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":91,"end":91,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":17,"end":17,"feature_id":"VAR_010348","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; most common mutation; reduction in the ability to promote microtubule assembly; accelerates aggregation of tau into filaments; dbSNP:rs63751273.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618}]},{"key":"site","label":"SITE","kind":"point","features":[{"begin":6,"end":6,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":10,"end":10,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":611,"original_end":611},{"begin":14,"end":14,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":56,"end":56,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":657,"original_end":657},{"begin":59,"end":59,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":86,"end":86,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":687,"original_end":687},{"begin":91,"end":91,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"other_bond_outliers","label":"BOND_OUTLIERS","kind":"numeric_series","features":[{"begin":16,"end":16,"feature_id":"BOND_OUTLIERS","type":"BOND_OUTLIERS","name":"BOND_OUTLIERS","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":16,"original_end":null,"values":[1.0]},{"begin":92,"end":92,"feature_id":"BOND_OUTLIERS","type":"BOND_OUTLIERS","name":"BOND_OUTLIERS","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.B","provenance_source":"PDB","original_begin":92,"original_end":null,"values":[1.0]}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":602},{"begin":6,"end":6,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":9,"end":9,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":610,"original_end":610},{"begin":14,"end":14,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":21,"end":21,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6,N6-dimethyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":40,"end":40,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":641,"original_end":641},{"begin":47,"end":47,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":65,"end":65,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Omega-N-methylarginine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":666,"original_end":666},{"begin":68,"end":68,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":72,"end":72,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":673,"original_end":673},{"begin":85,"end":85,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":1,"end":84,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Microtubule-binding domain","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":685}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":1,"end":21,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 2","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622},{"begin":22,"end":52,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 3","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":623,"original_end":653},{"begin":53,"end":84,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 4","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":685}]},{"key":"other_sequence_conflict","label":"SEQUENCE_CONFLICT","kind":"point","features":[{"begin":16,"end":16,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":21,"end":21,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":12,"end":12,"feature_id":"VAR_019663","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level; dbSNP:rs63750416.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":12,"end":12,"feature_id":"VAR_019664","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1/atypical PSNP1; heterozygosity may be a risk factor for both a PSNP1-like syndrome and Parkinson disease; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":16,"end":16,"feature_id":"VAR_064624","type":"SEQUENCE_VARIANT","name":null,"description":"In dbSNP:rs116733906.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":17,"end":17,"feature_id":"VAR_010349","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1 and CBD; reduction in the ability to promote microtubule assembly; dbSNP:rs63751438.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618},{"begin":19,"end":19,"feature_id":"VAR_037439","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1; dbSNP:rs63751391.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":620,"original_end":620},{"begin":21,"end":21,"feature_id":"VAR_010350","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; minimal parkinsonism; very early age of onset; dbSNP:rs63751165.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":33,"end":33,"feature_id":"VAR_037440","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750092.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":36,"end":36,"feature_id":"VAR_019665","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; markedly reduced ability of tau to promote microtubule assembly; dbSNP:rs63750635.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":637,"original_end":637},{"begin":53,"end":53,"feature_id":"VAR_010351","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; ultrastructural and biochemical characteristics indistinguishable from Alzheimer disease; accelerates aggregation of tau into filaments; dbSNP:rs63750570.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":654},{"begin":58,"end":58,"feature_id":"VAR_019666","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750711.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":659,"original_end":659},{"begin":68,"end":68,"feature_id":"VAR_019667","type":"SEQUENCE_VARIANT","name":null,"description":"In fatal respiratory hypoventilation; unusual apparent autosomal recessive inheritance; reduced binding to microtubules as well as increased fibrillization and aggregation; dbSNP:rs63750425.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":85,"end":85,"feature_id":"VAR_019668","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; 90% reduction in the rate of microtubule assembly; dbSNP:rs63751264.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":1,"end":21,"feature_id":"VSP_003181","type":"SPLICE_VARIANT","name":null,"description":"In isoform Tau-A, isoform Tau-B, isoform Tau-C and isoform Fetal-tau.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622}]}]},{"instance_id":"6GX5.A","entity_id":"1","label_asym_id":"A","auth_asym_id":"A","description":"Microtubule-associated protein tau","polymer_type":"polypeptide(L)","sequence":{"value":"KNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF","length":94},"alignments":[{"source":"UNIPROT","target_id":"P10636","target_sequence":"MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL","query_coverage":1.0,"query_length":94,"target_coverage":0.12401055408970976,"target_length":758,"orientation":null,"regions":[{"query_begin":1,"query_end":94,"target_begin":602,"target_end":695,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":2,"end":7,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":2,"original_end":7},{"begin":10,"end":15,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":10,"original_end":15},{"begin":21,"end":26,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":21,"original_end":26},{"begin":29,"end":30,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":29,"original_end":30},{"begin":34,"end":37,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":34,"original_end":37},{"begin":40,"end":41,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":40,"original_end":41},{"begin":44,"end":46,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":44,"original_end":46},{"begin":52,"end":70,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":52,"original_end":70},{"begin":75,"end":78,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":75,"original_end":78},{"begin":85,"end":93,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PROMOTIF","original_begin":85,"original_end":93}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":1,"end":1,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[2.0]},{"begin":14,"end":14,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":14,"original_end":null,"values":[1.0]},{"begin":17,"end":17,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":17,"original_end":null,"values":[3.0]},{"begin":25,"end":25,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":25,"original_end":null,"values":[1.0]},{"begin":27,"end":27,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":27,"original_end":null,"values":[1.0]},{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[2.0]},{"begin":56,"end":56,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":56,"original_end":null,"values":[4.0]},{"begin":71,"end":71,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":71,"original_end":null,"values":[2.0]},{"begin":74,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":74,"original_end":null,"values":[2.0]},{"begin":78,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":78,"original_end":null,"values":[4.0]},{"begin":91,"end":91,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":91,"original_end":null,"values":[2.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":1,"original_end":null,"values":[0.404,0.531,0.602,0.472,0.615,0.586,0.588,0.527,0.538,0.617,0.455,0.585,0.561,0.42,0.618,0.551,0.506,0.583,0.592,0.532,0.596,0.571,0.602,0.605,0.551,0.56,0.326,0.563,0.578,0.507,0.527,0.486,0.397,0.549,0.546,0.539,0.411,0.555,0.616,0.547,0.519,0.583,0.574,0.57,0.611,0.57,0.566,0.513,0.544,0.544,0.566,0.528,0.556,0.409,0.556,0.374,0.604,0.382,0.547,0.585,0.473,0.504,0.544,0.465,0.515,0.514,0.54,0.611,0.433,0.603,0.545,0.49,0.561,0.366,0.532,0.561,0.541,0.593,0.542,0.598,0.507,0.554,0.538,0.526,0.448,0.391,0.491,0.378,0.559,0.606,0.566,0.547,0.5,0.632]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":90,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[-0.94,-0.59,-0.59,-1.44,-0.59,-0.93,-0.86,-1.74,-1.88,-1.83,-1.8,-1.46,-1.5,-1.46,-1.41,-0.56,0.3,0.33,-0.06,-0.19,0.32,0.37,0.32,0.62,-0.31,-0.31,-0.24,0.1,-0.16,-0.34,0.0,-0.51,0.0,0.39,-0.47,0.11,-0.16,-0.08,-0.79,-0.92,-0.88,-1.34,-1.34,-1.34,-1.38,-1.41,-0.59,-0.59,-0.5,-0.84,-1.23,-0.77,-0.77,-0.92,-0.97,-1.82,-1.89,-1.33,-1.33,-0.99,-1.84,-0.96,-1.31,-0.97,-0.16,-0.04,-0.9,-0.01,0.0,0.08,0.04,-0.09,-0.04,-0.51,-0.17,-0.17,-1.1,-1.46,-0.6,-1.46,-1.36,-1.67,-2.06,-1.59,-1.28,-0.53]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.94,0.92,0.86,0.82,0.8,0.76,0.75,0.71,0.67,0.63,0.59,0.55,0.55,0.55,0.51,0.44,0.44,0.53,0.49,0.5,0.45,0.46,0.45,0.47,0.46,0.45,0.45,0.35,0.36,0.37,0.31,0.31,0.36,0.28,0.35,0.4,0.46,0.48,0.46,0.5,0.5,0.56,0.51,0.51,0.51,0.52,0.51,0.52,0.59,0.54,0.53,0.53,0.53,0.53,0.59,0.54,0.55,0.55,0.53,0.47,0.48,0.48,0.41,0.46,0.46,0.44,0.43,0.44,0.38,0.41,0.47,0.47,0.55,0.55,0.53,0.53,0.5,0.48,0.47,0.48,0.53,0.47,0.46,0.44,0.48,0.52,0.62,0.67,0.69,0.77,0.78,0.82,0.85,0.87]}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":94,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.44,0.44,0.46,0.47,0.49,0.51,0.53,0.54,0.56,0.56,0.56,0.56,0.56,0.54,0.54,0.52,0.5,0.49,0.48,0.48,0.48,0.48,0.48,0.48,0.49,0.48,0.48,0.49,0.48,0.48,0.47,0.46,0.45,0.44,0.44,0.43,0.44,0.43,0.43,0.43,0.44,0.44,0.45,0.47,0.47,0.48,0.48,0.48,0.49,0.49,0.49,0.49,0.49,0.5,0.5,0.5,0.5,0.49,0.49,0.49,0.49,0.49,0.48,0.47,0.45,0.45,0.44,0.44,0.44,0.44,0.45,0.45,0.45,0.46,0.46,0.47,0.48,0.49]}]},{"key":"pfam","label":"PFAM","kind":"range","features":[{"begin":1,"end":21,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":1,"original_end":21},{"begin":22,"end":52,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":22,"original_end":52},{"begin":53,"end":84,"feature_id":"PF00418","type":"PFAM","name":"Tau and MAP protein, tubulin-binding repeat (Tubulin-binding)","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6GX5_1","provenance_source":"Pfam","original_begin":53,"original_end":84}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":94,"feature_id":"PRO_0000072739","type":"CHAIN","name":null,"description":"Microtubule-associated protein tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":695},{"begin":14,"end":14,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":91,"end":91,"feature_id":null,"type":"CROSS_LINK","name":null,"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":17,"end":17,"feature_id":"VAR_010348","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; most common mutation; reduction in the ability to promote microtubule assembly; accelerates aggregation of tau into filaments; dbSNP:rs63751273.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618}]},{"key":"site","label":"SITE","kind":"point","features":[{"begin":6,"end":6,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":10,"end":10,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":611,"original_end":611},{"begin":14,"end":14,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":27,"end":27,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":47,"end":47,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":56,"end":56,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":657,"original_end":657},{"begin":59,"end":59,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":69,"end":69,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":670,"original_end":670},{"begin":85,"end":85,"feature_id":null,"type":"GLYCOSYLATION_SITE","name":null,"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686},{"begin":86,"end":86,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":687,"original_end":687},{"begin":91,"end":91,"feature_id":null,"type":"SITE","name":null,"description":"Not glycated","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":692,"original_end":692}]},{"key":"other_bond_outliers","label":"BOND_OUTLIERS","kind":"numeric_series","features":[{"begin":16,"end":16,"feature_id":"BOND_OUTLIERS","type":"BOND_OUTLIERS","name":"BOND_OUTLIERS","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":16,"original_end":null,"values":[1.0]},{"begin":92,"end":92,"feature_id":"BOND_OUTLIERS","type":"BOND_OUTLIERS","name":"BOND_OUTLIERS","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6GX5.A","provenance_source":"PDB","original_begin":92,"original_end":null,"values":[1.0]}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":602},{"begin":6,"end":6,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":607,"original_end":607},{"begin":9,"end":9,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":610,"original_end":610},{"begin":14,"end":14,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":615,"original_end":615},{"begin":21,"end":21,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6,N6-dimethyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":27,"end":27,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":628,"original_end":628},{"begin":33,"end":33,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":37,"end":37,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":638,"original_end":638},{"begin":40,"end":40,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":641,"original_end":641},{"begin":47,"end":47,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":648,"original_end":648},{"begin":59,"end":59,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":660,"original_end":660},{"begin":63,"end":63,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":664,"original_end":664},{"begin":65,"end":65,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Omega-N-methylarginine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":666,"original_end":666},{"begin":68,"end":68,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by PHK","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":72,"end":72,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":673,"original_end":673},{"begin":85,"end":85,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N6-acetyllysine; alternate","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":1,"end":84,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Microtubule-binding domain","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":685}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":1,"end":21,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 2","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622},{"begin":22,"end":52,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 3","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":623,"original_end":653},{"begin":53,"end":84,"feature_id":null,"type":"REPEAT","name":null,"description":"Tau/MAP 4","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":685}]},{"key":"other_sequence_conflict","label":"SEQUENCE_CONFLICT","kind":"point","features":[{"begin":16,"end":16,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":21,"end":21,"feature_id":null,"type":"SEQUENCE_CONFLICT","name":null,"description":"In Ref. 17; AA sequence.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":12,"end":12,"feature_id":"VAR_019663","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level; dbSNP:rs63750416.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":12,"end":12,"feature_id":"VAR_019664","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1/atypical PSNP1; heterozygosity may be a risk factor for both a PSNP1-like syndrome and Parkinson disease; reduced the ability of tau to promote microtubule assembly without having a significant effect on tau filament formation; effects at both the RNA and the protein level.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":613,"original_end":613},{"begin":16,"end":16,"feature_id":"VAR_064624","type":"SEQUENCE_VARIANT","name":null,"description":"In dbSNP:rs116733906.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":617,"original_end":617},{"begin":17,"end":17,"feature_id":"VAR_010349","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1 and CBD; reduction in the ability to promote microtubule assembly; dbSNP:rs63751438.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":618,"original_end":618},{"begin":19,"end":19,"feature_id":"VAR_037439","type":"SEQUENCE_VARIANT","name":null,"description":"In PSNP1; dbSNP:rs63751391.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":620,"original_end":620},{"begin":21,"end":21,"feature_id":"VAR_010350","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; minimal parkinsonism; very early age of onset; dbSNP:rs63751165.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":622,"original_end":622},{"begin":33,"end":33,"feature_id":"VAR_037440","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750092.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":634,"original_end":634},{"begin":36,"end":36,"feature_id":"VAR_019665","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; markedly reduced ability of tau to promote microtubule assembly; dbSNP:rs63750635.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":637,"original_end":637},{"begin":53,"end":53,"feature_id":"VAR_010351","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; ultrastructural and biochemical characteristics indistinguishable from Alzheimer disease; accelerates aggregation of tau into filaments; dbSNP:rs63750570.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":654,"original_end":654},{"begin":58,"end":58,"feature_id":"VAR_019666","type":"SEQUENCE_VARIANT","name":null,"description":"In FTD1; dbSNP:rs63750711.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":659,"original_end":659},{"begin":68,"end":68,"feature_id":"VAR_019667","type":"SEQUENCE_VARIANT","name":null,"description":"In fatal respiratory hypoventilation; unusual apparent autosomal recessive inheritance; reduced binding to microtubules as well as increased fibrillization and aggregation; dbSNP:rs63750425.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":669,"original_end":669},{"begin":85,"end":85,"feature_id":"VAR_019668","type":"SEQUENCE_VARIANT","name":null,"description":"In PIDB; 90% reduction in the rate of microtubule assembly; dbSNP:rs63751264.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":686,"original_end":686}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":1,"end":21,"feature_id":"VSP_003181","type":"SPLICE_VARIANT","name":null,"description":"In isoform Tau-A, isoform Tau-B, isoform Tau-C and isoform Fetal-tau.","value":null,"source":"UNIPROT","source_id":"P10636","provenance_source":null,"original_begin":602,"original_end":622}]}]}],"errors":[]}