{"schema_version":"1.0","pdb_id":"6LRQ","generated_at":"2026-09-07T10:29:52Z","status":"complete","coordinate_system":{"reference":"PDB_INSTANCE","index_base":1,"end_inclusive":true},"sources":{"sequence_coordinates_api":"https://sequence-coordinates.rcsb.org/graphql","annotation_collections":["UNIPROT","PDB_ENTITY","PDB_INSTANCE","PDB_INTERFACE"]},"chains":[{"instance_id":"6LRQ.F","entity_id":"1","label_asym_id":"F","auth_asym_id":"F","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AB2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":83,"feature_id":"AB3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":88,"end":96,"feature_id":"AB4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":50,"end":50,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":50,"original_end":null,"values":[1.0]},{"begin":52,"end":53,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[1.0,1.0]},{"begin":58,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0,1.0,4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[2.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[2.0]},{"begin":70,"end":70,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":70,"original_end":null,"values":[1.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,3.0]},{"begin":80,"end":80,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":80,"original_end":null,"values":[1.0]},{"begin":89,"end":89,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[1.0]},{"begin":94,"end":94,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.372,0.371,0.428,0.417,0.299,0.175,0.404,0.504,0.482,0.323,0.37,0.441,0.457,0.519,0.371,0.4,0.448,0.494,0.371,0.466,0.5,0.47,0.536,0.422,0.473,0.531,0.56,0.528,0.439,0.512,0.44,0.372,0.517,0.451,0.487,0.537,0.508,0.461,0.429,0.507,0.39,0.493,0.446,0.284,0.46,0.521,0.497,0.494,0.503,0.402,0.415,0.504,0.397,0.281,0.503,0.522,0.395,0.493,0.491,0.555,0.597,0.31,0.591]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqF1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.F","provenance_source":"PDB","original_begin":100,"original_end":140}]}]},{"instance_id":"6LRQ.E","entity_id":"1","label_asym_id":"E","auth_asym_id":"E","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AB2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":83,"feature_id":"AB3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":88,"end":96,"feature_id":"AB4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":44,"end":44,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":44,"original_end":null,"values":[1.0]},{"begin":46,"end":46,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":46,"original_end":null,"values":[2.0]},{"begin":49,"end":50,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":49,"original_end":null,"values":[1.0,1.0]},{"begin":52,"end":53,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[2.0,1.0]},{"begin":58,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0,1.0,4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[2.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[2.0]},{"begin":70,"end":70,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":70,"original_end":null,"values":[1.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,5.0]},{"begin":77,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":77,"original_end":null,"values":[1.0,1.0]},{"begin":80,"end":80,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":80,"original_end":null,"values":[1.0]},{"begin":89,"end":90,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[2.0,1.0]},{"begin":94,"end":94,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[2.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.378,0.428,0.407,0.37,0.368,0.106,0.413,0.525,0.498,0.36,0.496,0.4,0.464,0.527,0.406,0.395,0.473,0.479,0.455,0.572,0.502,0.527,0.474,0.449,0.448,0.539,0.482,0.489,0.423,0.468,0.368,0.329,0.561,0.472,0.488,0.519,0.517,0.45,0.491,0.479,0.41,0.534,0.455,0.328,0.482,0.565,0.533,0.489,0.496,0.391,0.478,0.488,0.485,0.283,0.487,0.472,0.464,0.533,0.545,0.542,0.582,0.306,0.556]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqE1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.E","provenance_source":"PDB","original_begin":100,"original_end":140}]}]},{"instance_id":"6LRQ.D","entity_id":"1","label_asym_id":"D","auth_asym_id":"D","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA8","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA9","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AB1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AB2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":83,"feature_id":"AB3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":88,"end":96,"feature_id":"AB4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":44,"end":44,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":44,"original_end":null,"values":[1.0]},{"begin":46,"end":46,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":46,"original_end":null,"values":[2.0]},{"begin":49,"end":49,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":49,"original_end":null,"values":[1.0]},{"begin":52,"end":52,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[1.0]},{"begin":58,"end":59,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0]},{"begin":61,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":61,"original_end":null,"values":[4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[2.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[1.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,2.0]},{"begin":77,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":77,"original_end":null,"values":[1.0,1.0]},{"begin":89,"end":90,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[1.0,1.0]},{"begin":94,"end":94,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.405,0.39,0.401,0.514,0.291,0.148,0.46,0.546,0.529,0.364,0.423,0.426,0.453,0.489,0.429,0.411,0.494,0.445,0.418,0.465,0.506,0.489,0.544,0.432,0.455,0.538,0.549,0.569,0.446,0.51,0.49,0.466,0.552,0.47,0.515,0.541,0.479,0.462,0.445,0.546,0.437,0.551,0.498,0.318,0.468,0.549,0.52,0.484,0.521,0.422,0.419,0.473,0.438,0.318,0.472,0.561,0.484,0.507,0.48,0.552,0.592,0.315,0.567]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqD1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.D","provenance_source":"PDB","original_begin":100,"original_end":140}]}]},{"instance_id":"6LRQ.C","entity_id":"1","label_asym_id":"C","auth_asym_id":"C","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":78,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":76,"original_end":78},{"begin":81,"end":83,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":81,"original_end":83},{"begin":88,"end":96,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":44,"end":44,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":44,"original_end":null,"values":[1.0]},{"begin":46,"end":46,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":46,"original_end":null,"values":[1.0]},{"begin":49,"end":49,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":49,"original_end":null,"values":[1.0]},{"begin":52,"end":52,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[1.0]},{"begin":58,"end":59,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0]},{"begin":61,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":61,"original_end":null,"values":[4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[3.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[2.0]},{"begin":70,"end":70,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":70,"original_end":null,"values":[2.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,3.0]},{"begin":77,"end":77,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":77,"original_end":null,"values":[1.0]},{"begin":80,"end":80,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":80,"original_end":null,"values":[1.0]},{"begin":83,"end":83,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":83,"original_end":null,"values":[1.0]},{"begin":89,"end":90,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[1.0,1.0]},{"begin":94,"end":95,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[1.0,1.0]},{"begin":97,"end":98,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":97,"original_end":null,"values":[1.0,1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.412,0.442,0.415,0.397,0.36,0.147,0.475,0.496,0.477,0.338,0.422,0.429,0.441,0.521,0.33,0.41,0.449,0.489,0.393,0.49,0.519,0.488,0.475,0.41,0.455,0.448,0.542,0.423,0.404,0.449,0.432,0.337,0.542,0.474,0.507,0.519,0.503,0.477,0.423,0.488,0.435,0.473,0.475,0.318,0.455,0.569,0.528,0.457,0.526,0.393,0.405,0.491,0.429,0.271,0.544,0.496,0.42,0.513,0.482,0.529,0.58,0.282,0.583]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqC1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.C","provenance_source":"PDB","original_begin":100,"original_end":140}]}]},{"instance_id":"6LRQ.B","entity_id":"1","label_asym_id":"B","auth_asym_id":"B","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":83,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":76,"end":83,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":88,"end":96,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":44,"end":47,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":44,"original_end":null,"values":[2.0,1.0,2.0,1.0]},{"begin":49,"end":50,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":49,"original_end":null,"values":[2.0,1.0]},{"begin":52,"end":53,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[3.0,1.0]},{"begin":58,"end":59,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0]},{"begin":61,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":61,"original_end":null,"values":[4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[3.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[2.0]},{"begin":70,"end":70,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":70,"original_end":null,"values":[3.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,6.0]},{"begin":76,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":76,"original_end":null,"values":[1.0,4.0,1.0]},{"begin":80,"end":80,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":80,"original_end":null,"values":[1.0]},{"begin":83,"end":83,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":83,"original_end":null,"values":[1.0]},{"begin":87,"end":87,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":87,"original_end":null,"values":[1.0]},{"begin":89,"end":90,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[2.0,1.0]},{"begin":94,"end":95,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[2.0,1.0]},{"begin":97,"end":98,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":97,"original_end":null,"values":[1.0,1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.426,0.404,0.352,0.496,0.336,0.083,0.471,0.515,0.517,0.358,0.467,0.417,0.441,0.496,0.436,0.447,0.493,0.451,0.446,0.505,0.54,0.564,0.504,0.446,0.448,0.552,0.555,0.508,0.429,0.441,0.502,0.392,0.547,0.486,0.523,0.548,0.457,0.472,0.456,0.515,0.432,0.544,0.502,0.363,0.474,0.497,0.577,0.474,0.538,0.358,0.45,0.455,0.455,0.305,0.491,0.514,0.507,0.526,0.498,0.526,0.56,0.317,0.51]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqB1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.B","provenance_source":"PDB","original_begin":100,"original_end":140}]}]},{"instance_id":"6LRQ.A","entity_id":"1","label_asym_id":"A","auth_asym_id":"A","description":"Alpha-synuclein","polymer_type":"polypeptide(L)","sequence":{"value":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","length":140},"alignments":[{"source":"UNIPROT","target_id":"P37840","target_sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA","query_coverage":1.0,"query_length":140,"target_coverage":1.0,"target_length":140,"orientation":null,"regions":[{"query_begin":1,"query_end":140,"target_begin":1,"target_end":140,"exon_shift":null}]}],"tracks":[{"key":"secondary_structure","label":"SECONDARY STRUCTURE","kind":"range","features":[{"begin":48,"end":55,"feature_id":"AA1","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":48,"original_end":55},{"begin":61,"end":62,"feature_id":"AA2","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":61,"original_end":62},{"begin":65,"end":66,"feature_id":"AA3","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":65,"original_end":66},{"begin":70,"end":71,"feature_id":"AA4","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":70,"original_end":71},{"begin":76,"end":83,"feature_id":"AA6","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":76,"end":83,"feature_id":"AA5","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":76,"original_end":83},{"begin":88,"end":96,"feature_id":"AA7","type":"SHEET","name":"sheet","description":"parallel sense sheet","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PROMOTIF","original_begin":88,"original_end":96}]},{"key":"atomic_clashes","label":"ATOMIC CLASHES","kind":"numeric_series","features":[{"begin":37,"end":37,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[1.0]},{"begin":44,"end":45,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":44,"original_end":null,"values":[1.0,1.0]},{"begin":47,"end":47,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":47,"original_end":null,"values":[1.0]},{"begin":49,"end":50,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":49,"original_end":null,"values":[1.0,1.0]},{"begin":52,"end":53,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":52,"original_end":null,"values":[2.0,1.0]},{"begin":58,"end":59,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":58,"original_end":null,"values":[3.0,1.0]},{"begin":61,"end":61,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":61,"original_end":null,"values":[4.0]},{"begin":65,"end":66,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":65,"original_end":null,"values":[2.0,1.0]},{"begin":68,"end":68,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":68,"original_end":null,"values":[1.0]},{"begin":70,"end":70,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":70,"original_end":null,"values":[1.0]},{"begin":72,"end":74,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":72,"original_end":null,"values":[1.0,1.0,3.0]},{"begin":76,"end":78,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":76,"original_end":null,"values":[1.0,1.0,1.0]},{"begin":80,"end":80,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":80,"original_end":null,"values":[1.0]},{"begin":87,"end":87,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":87,"original_end":null,"values":[1.0]},{"begin":89,"end":90,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":89,"original_end":null,"values":[1.0,2.0]},{"begin":94,"end":94,"feature_id":"CLASHES","type":"CLASHES","name":"CLASHES","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":94,"original_end":null,"values":[1.0]}]},{"key":"q_score","label":"Q-SCORE","kind":"numeric_series","features":[{"begin":37,"end":99,"feature_id":"Q_SCORE","type":"Q_SCORE","name":"Q_SCORE","description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":37,"original_end":null,"values":[0.419,0.434,0.39,0.483,0.335,0.102,0.464,0.491,0.497,0.363,0.398,0.442,0.443,0.508,0.373,0.421,0.467,0.482,0.405,0.492,0.512,0.497,0.49,0.408,0.447,0.431,0.55,0.449,0.4,0.445,0.507,0.482,0.533,0.472,0.528,0.519,0.47,0.479,0.412,0.518,0.433,0.507,0.477,0.312,0.453,0.574,0.525,0.45,0.528,0.422,0.393,0.495,0.429,0.273,0.519,0.552,0.477,0.492,0.462,0.528,0.598,0.303,0.578]}]},{"key":"hydropathy","label":"HYDROPATHY","kind":"numeric_series","features":[{"begin":5,"end":136,"feature_id":null,"type":"HYDROPATHY","name":"Hydropathy values","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"biojava-7.2.4","original_begin":5,"original_end":null,"values":[0.67,0.02,0.61,-0.29,-0.99,-1.24,-0.34,0.17,-0.06,0.23,0.87,0.28,0.28,0.59,0.2,-0.66,-1.17,-0.9,-0.9,-1.49,-0.9,-0.27,-0.23,-0.23,0.08,-0.31,-1.17,-1.41,-0.56,-0.33,-0.68,-0.17,0.22,0.21,0.21,0.52,0.13,-0.72,-1.19,-0.58,-0.58,-0.89,-0.84,0.06,0.06,0.41,1.27,1.51,0.66,-0.24,0.03,-0.36,-1.21,-1.52,-0.98,-1.52,-2.11,-1.26,-0.87,-0.83,-0.2,0.66,1.51,0.97,1.0,1.86,1.31,1.56,2.07,2.07,1.21,0.31,0.31,0.82,-0.03,0.0,0.0,-0.51,-0.8,0.09,0.72,1.0,0.73,1.04,1.04,1.16,1.67,1.32,0.39,-0.2,-0.79,-0.57,-0.53,-0.92,-1.62,-2.48,-2.43,-2.04,-1.46,-1.24,-2.06,-2.4,-2.01,-1.12,-0.31,-0.31,-0.66,-0.64,-0.64,0.21,0.21,0.08,-0.81,-1.62,-1.62,-1.03,-1.39,-1.6,-1.86,-1.64,-1.56,-1.56,-1.56,-1.21,-1.56,-1.8,-1.8,-2.16,-2.37,-2.46,-2.46,-1.87]}]},{"key":"disorder","label":"DISORDER","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER","name":"Disordered regions","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"IUPred2(short)","original_begin":1,"original_end":null,"values":[0.81,0.76,0.74,0.69,0.6,0.51,0.43,0.36,0.28,0.25,0.2,0.22,0.21,0.27,0.33,0.3,0.28,0.29,0.31,0.28,0.28,0.31,0.31,0.29,0.3,0.35,0.37,0.35,0.33,0.31,0.31,0.31,0.31,0.31,0.3,0.31,0.36,0.35,0.29,0.35,0.38,0.33,0.33,0.33,0.29,0.25,0.27,0.3,0.33,0.38,0.44,0.44,0.38,0.39,0.4,0.36,0.35,0.35,0.37,0.36,0.28,0.27,0.32,0.27,0.27,0.29,0.27,0.23,0.23,0.23,0.23,0.17,0.19,0.24,0.22,0.22,0.27,0.2,0.17,0.18,0.2,0.25,0.26,0.2,0.2,0.19,0.21,0.29,0.33,0.28,0.3,0.29,0.34,0.35,0.37,0.4,0.38,0.41,0.5,0.55,0.58,0.57,0.53,0.55,0.65,0.67,0.71,0.69,0.69,0.71,0.79,0.79,0.83,0.82,0.76,0.76,0.74,0.78,0.76,0.78,0.78,0.79,0.79,0.85,0.86,0.78,0.84,0.83,0.89,0.86,0.87,0.87,0.9,0.91,0.93,0.97,0.98,0.99,0.99,1.0]},{"begin":100,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Disordered","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":100,"original_end":140}]},{"key":"disordered_binding","label":"DISORDERED BINDING","kind":"numeric_series","features":[{"begin":1,"end":140,"feature_id":null,"type":"DISORDER_BINDING","name":"Disordered binding sites","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"Anchor2","original_begin":1,"original_end":null,"values":[0.38,0.39,0.39,0.4,0.4,0.41,0.41,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.44,0.44,0.43,0.43,0.43,0.43,0.43,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.42,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.43,0.44,0.45,0.46,0.48,0.5,0.51,0.53,0.54,0.56,0.57,0.57,0.56,0.57,0.55,0.53,0.52,0.51,0.5,0.5,0.48,0.47,0.48,0.51,0.53,0.58,0.63,0.68,0.72,0.77,0.81,0.85,0.88,0.89,0.9,0.9,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.91,0.92,0.92,0.93,0.94,0.94,0.95,0.96,0.96,0.97,0.97,0.98,0.98,0.98,0.98,0.98,0.98]}]},{"key":"ecod","label":"ECOD","kind":"range","features":[{"begin":37,"end":99,"feature_id":"e6lrqA1","type":"ECOD","name":null,"description":null,"value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"ECOD","original_begin":37,"original_end":99}]},{"key":"molecule_processing","label":"MOLECULE PROCESSING","kind":"range","features":[{"begin":1,"end":140,"feature_id":"PRO_0000184022","type":"CHAIN","name":null,"description":"Alpha-synuclein","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":140}]},{"key":"mutagenesis","label":"MUTAGENESIS","kind":"point","features":[{"begin":2,"end":2,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":2,"original_end":2},{"begin":35,"end":35,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":35,"original_end":35},{"begin":39,"end":39,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":39,"original_end":39},{"begin":50,"end":50,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs copper-binding.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"monomer_feature_1","type":"MUTATION","name":"engineered mutation","description":null,"value":null,"source":"PDB_ENTITY","source_id":"6LRQ_1","provenance_source":"PDB","original_begin":53,"original_end":53},{"begin":57,"end":57,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Increases oligomerization.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":57},{"begin":67,"end":71,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":67,"original_end":71},{"begin":71,"end":82,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":71,"original_end":82},{"begin":76,"end":76,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":76},{"begin":76,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Impairs polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":76,"original_end":77},{"begin":77,"end":77,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":77,"original_end":77},{"begin":78,"end":78,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Does not affect polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":78,"original_end":78},{"begin":85,"end":94,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Reduces polymerization into amyloid fibrils.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":85,"original_end":94},{"begin":125,"end":125,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"Abolishes osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":133,"end":133,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":133,"original_end":133},{"begin":136,"end":136,"feature_id":null,"type":"MUTAGENESIS_SITE","name":null,"description":"No effect on osmotic stress-induced phosphorylation.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":136,"original_end":136}]},{"key":"other_compositionally_biased_region","label":"COMPOSITIONALLY_BIASED_REGION","kind":"range","features":[{"begin":112,"end":140,"feature_id":null,"type":"COMPOSITIONALLY_BIASED_REGION","name":null,"description":"Acidic residues","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":112,"original_end":140}]},{"key":"other_modified_residue","label":"MODIFIED_RESIDUE","kind":"point","features":[{"begin":1,"end":1,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"N-acetylmethionine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":1,"original_end":1},{"begin":87,"end":87,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":87,"original_end":87},{"begin":125,"end":125,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphotyrosine; by FYN","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":125,"original_end":125},{"begin":129,"end":129,"feature_id":null,"type":"MODIFIED_RESIDUE","name":null,"description":"Phosphoserine; by GRK2, PLK2, CK2, CK1 and GRK5","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":129,"original_end":129}]},{"key":"other_region_of_interest","label":"REGION_OF_INTEREST","kind":"range","features":[{"begin":20,"end":67,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":67},{"begin":111,"end":140,"feature_id":null,"type":"REGION_OF_INTEREST","name":null,"description":"Interaction with SERF1A","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":111,"original_end":140}]},{"key":"other_repeat","label":"REPEAT","kind":"range","features":[{"begin":20,"end":30,"feature_id":null,"type":"REPEAT","name":null,"description":"1","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":20,"original_end":30},{"begin":31,"end":41,"feature_id":null,"type":"REPEAT","name":null,"description":"2","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":31,"original_end":41},{"begin":42,"end":56,"feature_id":null,"type":"REPEAT","name":null,"description":"3; approximate","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":42,"original_end":56},{"begin":57,"end":67,"feature_id":null,"type":"REPEAT","name":null,"description":"4","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":57,"original_end":67}]},{"key":"other_sequence_variant","label":"SEQUENCE_VARIANT","kind":"point","features":[{"begin":30,"end":30,"feature_id":"VAR_007957","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on oligomerization; dbSNP:rs104893878.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":30,"original_end":30},{"begin":46,"end":46,"feature_id":"VAR_022703","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes; increases oligomerization; dbSNP:rs104893875.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":46,"original_end":46},{"begin":50,"end":50,"feature_id":"VAR_070171","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on protein structure; no effect on phosphorylation of the protein; no effect on membrane- and lipid-binding; increases oligomerization; increases fibril formation; increases secretion of the protein; impairs copper-binding; dbSNP:rs201106962.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":50,"original_end":50},{"begin":53,"end":53,"feature_id":"VAR_007454","type":"SEQUENCE_VARIANT","name":null,"description":"In PARK1; no effect on osmotic stress-induced phosphorylation; increases oligomerization; dbSNP:rs104893877.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":53,"original_end":53}]},{"key":"other_splice_variant","label":"SPLICE_VARIANT","kind":"range","features":[{"begin":41,"end":54,"feature_id":"VSP_006363","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-5.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":41,"original_end":54},{"begin":103,"end":130,"feature_id":"VSP_006364","type":"SPLICE_VARIANT","name":null,"description":"In isoform 2-4.","value":null,"source":"UNIPROT","source_id":"P37840","provenance_source":null,"original_begin":103,"original_end":130}]},{"key":"other_unobserved_atom_xyz","label":"UNOBSERVED_ATOM_XYZ","kind":"point","features":[{"begin":42,"end":42,"feature_id":"1","type":"UNOBSERVED_ATOM_XYZ","name":"partially modeled residue","description":"Some atom coordinates in this residue are not reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":42,"original_end":42}]},{"key":"other_unobserved_residue_xyz","label":"UNOBSERVED_RESIDUE_XYZ","kind":"range","features":[{"begin":1,"end":36,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":1,"original_end":36},{"begin":100,"end":140,"feature_id":"1","type":"UNOBSERVED_RESIDUE_XYZ","name":"unmodeled residue","description":"No coordinates for this residue are reported in model 1","value":null,"source":"PDB_INSTANCE","source_id":"6LRQ.A","provenance_source":"PDB","original_begin":100,"original_end":140}]}]}],"errors":[]}